Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28994891 | 0.80 | MAOB (0.50) | KDM4ESMN1; SMN2ALDH1A1CYP19A1MAPT | |
| SCHEMBL30310041 | 0.80 | MAOB (0.50) | KDM4ESMN1; SMN2ALDH1A1CYP19A1MAPT | |
| SCHEMBL8395052 | 0.80 | KDM4E (0.51) | KDM4ESMN1; SMN2ALDH1A1HTTCYP1A2 | |
| SCHEMBL8434880 | 0.79 | BACE1 (0.52) | SMN1; SMN2LMNAHTT | |
| SCHEMBL198917 | 0.78 | KDM4E (0.59) | KDM4ESMN1; SMN2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL15684685 | 0.76 | CYP2D6 (0.54) | KDM4ESMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL9179120 | 0.75 | MAPT (0.43) | KDM4ESMN1; SMN2ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL9325859 | 0.75 | FPR2 (0.47) | ALDH1A1MAPTKMT2AMEN1FPR2 | |
| SCHEMBL7004490 | 0.73 | GPBAR1 (0.64) | KDM4ESMN1; SMN2LMNAALDH1A1GAA | |
| SCHEMBL15473215 | 0.73 | KMT2A (0.57) | KDM4ESMN1; SMN2LMNAALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0141847-A1 | PYRIDAZINONE, PREPARATION PROCESS THEREOF AND UTILISATION THEREOF, DRUGS CONTAINING PYRIDAZINONE | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1985-05-22 | — | — | EP | disclosed |
| WO-1984004522-A1 | PYRIDAZINONE, PREPARATION PROCESS THEREOF AND UTILISATION THEREOF, DRUGS CONTAINING PYRIDAZINONE | BYK GULDEN LOMBERG CHEM FAB (DE) | 1984-11-22 | — | — | WO | disclosed |