Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | F2R | P25116 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.42 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.42 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7765889 | 0.85 | POLB (0.76) | POLBRAB9ANR4A1TDP1SMN1; SMN2 | |
| SCHEMBL11235452 | 0.82 | POLB (1.00) | POLBRAB9ANR4A1TDP1SMN1; SMN2 | |
| SCHEMBL9821067 | 0.81 | POLB (0.69) | POLBRAB9ANR4A1TDP1SMN1; SMN2 | |
| SCHEMBL9114491 | 0.79 | POLB (0.77) | POLBRAB9ANR4A1TDP1SMN1; SMN2 | |
| SCHEMBL27996290 | 0.78 | POLB (0.43) | POLBTDP1SMN1; SMN2GAAKMT2A | |
| SCHEMBL7659979 | 0.77 | HTT (0.54) | RAB9ATDP1SMN1; SMN2NPC1KMT2A | |
| SCHEMBL6174178 | 0.75 | HSP90AB1 (0.48) | POLBRAB9ASMN1; SMN2GAAKMT2A | |
| SCHEMBL847574 | 0.75 | POLB (0.49) | POLBRAB9ANR4A1TDP1SMN1; SMN2 | |
| SCHEMBL22614748 | 0.74 | HSP90AB1 (0.47) | POLBRAB9ATDP1SMN1; SMN2NPC1 | |
| SCHEMBL27306343 | 0.74 | HSP90AB1 (0.67) | POLBRAB9ANPC1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0052442-B1 | HETEROCYCLIC COMPOUNDS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-09-11 | — | — | EP | disclosed |
| EP-0052442-A1 | Heterocyclic compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-05-26 | — | — | EP | disclosed |