Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.65 |
| ▸ | RAB9A | P51151 | 7/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | NPC1 | O15118 | 6/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | ALPL | P05186 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.46 |
| ▸ | RELA | Q04206 | 3/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1376637 | 0.79 | LMNA (1.00) | LMNARAB9AMAPTNPC1MAPK1 | |
| SCHEMBL1436161 | 0.77 | LMNA (0.58) | LMNARAB9AMAPTNPC1MAPK1 | |
| SCHEMBL8682877 | 0.76 | ALPL (0.46) | LMNARAB9AMAPTNPC1MEN1 | |
| SCHEMBL10968405 | 0.76 | TDP1 (0.46) | LMNARAB9AMAPTNPC1MAPK1 | |
| SCHEMBL1753039 | 0.75 | MAPT (0.61) | LMNARAB9AMAPTNPC1MAPK1 | |
| SCHEMBL3367047 | 0.73 | LMNA (0.53) | LMNARAB9AMAPTNPC1MAPK1 | |
| SCHEMBL1181434 | 0.73 | RAB9A (1.00) | LMNARAB9AMAPTNPC1MAPK1 | |
| SCHEMBL13425914 | 0.73 | RAB9A (0.69) | LMNARAB9AMAPTNPC1MAPK1 | |
| SCHEMBL10760024 | 0.71 | PDE4A (0.56) | LMNARAB9AMAPTNPC1MAPK1 | |
| SCHEMBL10758184 | 0.71 | PDE4A (0.55) | LMNARAB9AMAPTNPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0141847-A1 | PYRIDAZINONE, PREPARATION PROCESS THEREOF AND UTILISATION THEREOF, DRUGS CONTAINING PYRIDAZINONE | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1985-05-22 | — | — | EP | disclosed |
| WO-1984004521-A1 | PYRIDAZINONES, THEIR PREPARATION AND USE, AND MEDICAMENTS CONTAINING PYRIDAZINONES | BYK GULDEN LOMBERG CHEM FAB (DE) | 1984-11-22 | — | — | WO | disclosed |
| WO-1984004522-A1 | PYRIDAZINONE, PREPARATION PROCESS THEREOF AND UTILISATION THEREOF, DRUGS CONTAINING PYRIDAZINONE | BYK GULDEN LOMBERG CHEM FAB (DE) | 1984-11-22 | — | — | WO | disclosed |