Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 10/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10933747 | 0.63 | NPY5R (0.37) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4159209 | 0.62 | ALDH1A1 (0.39) | XIAPMAPTKDM4EALDH1A1 | |
| SCHEMBL12890455 | 0.59 | TSHR (0.54) | POLBMAPTSMN1; SMN2TP53KDM4E | |
| SCHEMBL13482127 | 0.58 | PKN1 (0.44) | POLBMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL866759 | 0.58 | PKN1 (0.47) | POLBMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL10856741 | 0.57 | SHMT2 (0.39) | XIAPALOX5MAPTKDM4EMEN1 | |
| SCHEMBL21146034 | 0.57 | PDCD1 (0.39) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL31252938 | 0.56 | MEN1 (0.45) | POLBSMN1; SMN2KDM4EMEN1ALDH1A1 | |
| SCHEMBL9994867 | 0.56 | GRM4 (0.82) | GRM4KCNH2 | |
| SCHEMBL5902421 | 0.55 | CA12 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154190-A1 | Pyridones | MERCK PATENT GmbH (DE) | 1985-09-11 | — | — | EP | disclosed |