Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | APAF1 | O14727 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | UBE2N | P61088 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10969890 | 0.88 | ADRA1A (0.62) | ADRA1AADRA1BKDM4EAPAF1ALDH1A1 | |
| SCHEMBL11075869 | 0.84 | ADRA1D (0.56) | ADRA1AADRA1B | |
| SCHEMBL10967958 | 0.84 | ADRA1A (0.60) | ADRA1AADRA1B | |
| SCHEMBL10968133 | 0.83 | KDM4E (0.61) | KDM4EAPAF1ALDH1A1POLBMAPT | |
| Water SCHEMBL10614118 | 0.83 | ADRA1D (0.55) | ADRA1AADRA1B | |
| Water SCHEMBL10614131 | 0.83 | ADRA1D (0.55) | ADRA1AADRA1B | |
| SCHEMBL31187488 | 0.83 | KDM4E (0.82) | ADRA1AADRA1BKDM4EAPAF1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL29393496 | 0.82 | POLB (0.80) | ADRA1AADRA1BKDM4EAPAF1ALDH1A1 | |
| SCHEMBL10967477 | 0.82 | — | — | |
| SCHEMBL11046159 | 0.81 | KDM4E (0.61) | ADRA1AADRA1BKDM4EAPAF1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0055583-B1 | ANTIHYPERTENSIVES | Pfizer Limited (GB) | 1985-08-28 | — | — | EP | disclosed |
| US-4483859-A | 4-Amino-6, 7-dimethoxy-2-(4-heteroaryl-piperazino) quinazoline _antihypertensives | PFIZER INC. (US) | 1984-11-20 | — | — | US | disclosed |
| US-4483857-A | 4-Amino-6,7-dimethoxy-2-(4-heteroaryl-piperazino)quinazoline antihypertensives | PFIZER INC. (US) | 1984-11-20 | — | — | US | disclosed |
| US-4435401-A | 4-Amino-6,7-dimethoxy-2-(4-heteroaryl-piperazino)quinazoline antihypertensives | PFIZER INC. (US) | 1984-03-06 | — | — | US | disclosed |
| EP-0055583-A1 | Antihypertensives | Pfizer Limited (GB) | 1982-07-07 | — | — | EP | disclosed |