SCHEMBL10967705

SCHEMBL10967705

O=C(Nc1ccccc1)c1cc2cc(Br)ccc2cc1O

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.64
KMT2A Q03164 4/20 0.64
POLB P06746 2/20 0.64
KDM4E B2RXH2 1/20 0.64
MAPT P10636 1/20 0.64
MCL1 Q07820 1/20 0.64
NPSR1 Q6W5P4 1/20 0.64
SRC P12931 1/20 0.60
NPC1 O15118 3/20 0.59
RAB9A P51151 3/20 0.59
F12 P00748 1/20 0.59
CASP3 P42574 1/20 0.57
SENP7 Q9BQF6 1/20 0.57
SENP6 Q9GZR1 1/20 0.57
PLG P00747 3/20 0.56
KLK1 P06870 2/20 0.56
KLK6 Q92876 2/20 0.56
PLAU P00749 2/20 0.55
F2 P00734 1/20 0.55
F10 P00742 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10340544 0.87 KMT2A (0.77) MEN1KMT2APOLBMAPTNPC1
SCHEMBL14585765 0.86 MEN1 (0.72) MEN1KMT2APOLBKDM4EMAPT
SCHEMBL57970 0.86 MEN1 (0.77) MEN1KMT2APOLBKDM4EMAPT
SCHEMBL30084384 0.86 MEN1 (0.77) MEN1KMT2APOLBKDM4EMAPT
SCHEMBL29890853 0.86 MEN1 (0.77) MEN1KMT2APOLBKDM4EMAPT
SCHEMBL2760088 0.85 SRC (0.81) MEN1KMT2APOLBKDM4EMAPT
SCHEMBL6575251 0.84 PLAU (0.64) MEN1KMT2APOLBKDM4EMAPT
SCHEMBL2129288 0.84 P2RX1 (0.71) MEN1KMT2APOLBMAPTSRC
SCHEMBL330113 0.83 TMPRSS4 (0.67) MEN1KMT2APOLBKDM4ENPC1
SCHEMBL30343477 0.83 TMPRSS4 (0.67) MEN1KMT2APOLBKDM4ENPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4496727-A ORGANIC PIGMENTS; PLASTICS; LACQUERS; INKS; COATINGS; COLOR FASTNESS CIBA-GEIGY CORPORATION (US) 1985-01-29 US disclosed
US-4385174-A FOR PIGMENTS CIBA-GEIGY CORPORATION (US) 1983-05-24 US disclosed