Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | LDHA | P00338 | 2/20 | 0.49 |
| ▸ | PPOX | P50336 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 6/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10969004 | 0.84 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1POLBHPGDTSHR | |
| SCHEMBL10969914 | 0.84 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1POLBHPGDTSHR | |
| SCHEMBL10830483 | 0.81 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1POLBHPGDTSHR | |
| SCHEMBL10968560 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1POLBHPGDTSHR | |
| SCHEMBL10829908 | 0.79 | MEN1 (0.61) | SMN1; SMN2ALDH1A1POLBHPGDTSHR | |
| SCHEMBL7015882 | 0.79 | ALOX5 (0.65) | SMN1; SMN2ALDH1A1POLBHPGDTSHR | |
| SCHEMBL3497943 | 0.78 | SMN1; SMN2 (0.84) | SMN1; SMN2ALDH1A1POLBHPGDTSHR | |
| SCHEMBL10969057 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1POLBHPGDTSHR | |
| SCHEMBL10968385 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1POLBHPGDTSHR | |
| SCHEMBL10969594 | 0.76 | LDHA (0.55) | SMN1; SMN2ALDH1A1POLBHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0137426-A2 | 2-Mercaptothiazole derivatives, process for their preparation and utilization of 2-mercaptothiazole derivatives in pharmaceutical compounds | BAYER AG (DE) | 1985-04-17 | — | — | EP | disclosed |