Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | TYMP | P19971 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | IDE | P14735 | 1/20 | 0.30 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10968412 | 0.81 | JAK2 (0.45) | PDE3BPDE3ATYMPJAK2THRB | |
| SCHEMBL10970603 | 0.75 | CREBBP (0.40) | PDE3BPDE3ATYMPNSD2ABL1 | |
| SCHEMBL10926001 | 0.75 | PDE3B (0.34) | PDE3BPDE3ATYMPNSD2ABL1 | |
| SCHEMBL10876599 | 0.69 | PDE3B (0.73) | PDE3BPDE3A | |
| SCHEMBL9786590 | 0.67 | L3MBTL1 (0.48) | PDE3BPDE3ATYMPJAK2THRB | |
| SCHEMBL10876269 | 0.67 | HPGDS (0.42) | PDE3BPDE3AGAAL3MBTL1 | |
| SCHEMBL15320556 | 0.65 | JAK2 (0.42) | TYMPJAK2THRBPDPK1GAA | |
| SCHEMBL5209445 | 0.65 | JAK2 (0.42) | TYMPJAK2THRBPDPK1TDP1 | |
| Urea SCHEMBL9301106 | 0.62 | LMNA (0.46) | TYMPJAK2THRBGAATDP1 | |
| SCHEMBL10811057 | 0.58 | PDE3B (0.51) | PDE3BPDE3ANSD2ABL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064705-B1 | 5-AMINOMETHYL-2,3-DIHYDRO-2-OXO-1H-IMIDAZOLE-4-CARBOXYLIC ACID DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-06-18 | — | — | EP | disclosed |
| EP-0064706-B1 | 5-(4-PHENYL-1-PIPERIDINYL)METHYL-2,3-DIHYDRO-2-OXO-1H-IMIDAZOLE-4-CARBOXYLIC ACID DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-07-03 | — | — | EP | disclosed |
| US-4371737-A | CARDIOTONICS, ANTIHYPERTENSIUES AND ANTITHROMBOTIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-02-01 | — | — | US | disclosed |
| EP-0064705-A1 | 5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-17 | — | — | EP | disclosed |
| EP-0064706-A1 | 5-(4-Phenyl-1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-17 | — | — | EP | disclosed |
| US-4329470-A | CORDIOTONIC, HYPOTENSIVE, ANTITHROMBOSIS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-05-11 | — | — | US | disclosed |