Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA known ✓ | P35790 | 10/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7166354 | 0.98 | ALDH1A1 (0.66) | ALDH1A1KDM4ERAB9ALMNACHKA | |
| SCHEMBL1108034 | 0.98 | ALDH1A1 (0.66) | ALDH1A1KDM4ERAB9ALMNACHKA | |
| Hydrochloric Acid SCHEMBL28357009 | 0.96 | ALDH1A1 (0.64) | ALDH1A1KDM4ERAB9ALMNACHKA | |
| Hydrochloric Acid SCHEMBL27637987 | 0.96 | ALDH1A1 (0.64) | ALDH1A1KDM4ERAB9ALMNACHKA | |
| SCHEMBL1108062 | 0.91 | ALDH1A1 (0.62) | ALDH1A1KDM4ERAB9ALMNACHKA | |
| Bromide SCHEMBL15361681 | 0.90 | CHKA (0.55) | ALDH1A1KDM4ERAB9ALMNACHKA | |
| Bromide SCHEMBL15361505 | 0.89 | CHKA (0.58) | ALDH1A1KDM4ERAB9ALMNACHKA | |
| SCHEMBL9999526 | 0.88 | CHKA (0.52) | ALDH1A1KDM4ERAB9ALMNACHKA | |
| Benzyl Viologen SCHEMBL1930045 | 0.88 | ALDH1A1 (0.78) | ALDH1A1KDM4ERAB9ALMNACHKA | |
| Benzyl Viologen SCHEMBL4079047 | 0.88 | ALDH1A1 (0.71) | ALDH1A1KDM4ERAB9ALMNACHKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0068880-B1 | PHOTOGRAPHIC ELEMENTS CAPABLE OF PROVIDING OXOINDOLIZINE AND OXOINDOLIZINIUM DYE COMPOUNDS | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1985-08-07 | — | — | EP | disclosed |
| EP-0068876-B1 | OXOINDOLIZINE AND OXOINDOLIZINIUM DYES AND PROCESSES FOR THEIR PREPARATION | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1985-04-03 | — | — | EP | disclosed |
| EP-0068876-A1 | Oxoindolizine and oxoindolizinium dyes and processes for their preparation | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1983-01-05 | — | — | EP | disclosed |
| EP-0068880-A1 | Photographic elements capable of providing oxoindolizine and oxoindolizinium dye compounds | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1983-01-05 | — | — | EP | disclosed |