Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.52 |
| ▸ | CHKA | P35790 | 8/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PRKCG | P05129 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | PRKX | P51817 | 1/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1108034 | 1.00 | ALDH1A1 (0.66) | ALDH1A1KDM4ERAB9ALMNANOTUM | |
| Bromide SCHEMBL10969375 | 0.98 | ALDH1A1 (0.64) | ALDH1A1KDM4ERAB9ALMNANOTUM | |
| Hydrochloric Acid SCHEMBL27637987 | 0.98 | ALDH1A1 (0.64) | ALDH1A1KDM4ERAB9ALMNANOTUM | |
| Hydrochloric Acid SCHEMBL28357009 | 0.98 | ALDH1A1 (0.64) | ALDH1A1KDM4ERAB9ALMNANOTUM | |
| SCHEMBL1108062 | 0.93 | ALDH1A1 (0.62) | ALDH1A1KDM4ERAB9ALMNANOTUM | |
| SCHEMBL9999526 | 0.90 | CHKA (0.52) | ALDH1A1KDM4ERAB9ALMNANOTUM | |
| Benzyl Viologen SCHEMBL1930045 | 0.90 | ALDH1A1 (0.78) | ALDH1A1KDM4ERAB9ALMNACHKA | |
| Bromide SCHEMBL15361681 | 0.88 | CHKA (0.55) | ALDH1A1KDM4ERAB9ALMNACHKA | |
| Benzyl Viologen SCHEMBL599497 | 0.88 | ALDH1A1 (0.75) | ALDH1A1KDM4ERAB9ALMNACHKA | |
| Hydrochloric Acid SCHEMBL1248547 | 0.88 | ALDH1A1 (0.75) | ALDH1A1KDM4ERAB9ALMNACHKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6569361-B1 | Polycondensation or polyaddition of electrochromic monomers are used in devices for variable transparency | BAYER AKTIENGESELLSCHAFT (DE) | 2003-05-27 | — | — | US | disclosed |