Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.66 |
| ▸ | HTR1A | P08908 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | DRD2 | P14416 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | DRD4 | P21917 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | DRD3 | P35462 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10970512 | 0.97 | TDP1 (0.62) | TDP1HTR1ACYP1A2CYP3A4MAPT | |
| SCHEMBL10971148 | 0.93 | DRD2 (0.56) | TDP1HTR1ACYP1A2CYP3A4MAPT | |
| SCHEMBL10970196 | 0.89 | HTR1A (0.59) | TDP1HTR1ACYP1A2CYP3A4MAPT | |
| SCHEMBL10971123 | 0.88 | HTR1A (0.58) | TDP1HTR1ACYP1A2CYP3A4MAPT | |
| SCHEMBL10968427 | 0.88 | HTR1A (0.58) | TDP1HTR1ACYP1A2CYP3A4MAPT | |
| SCHEMBL10355142 | 0.86 | TDP1 (0.85) | TDP1HTR1ACYP1A2CYP3A4MAPT | |
| SCHEMBL10972154 | 0.85 | HTR1A (0.55) | TDP1HTR1ACYP1A2CYP3A4MAPT | |
| SCHEMBL10968567 | 0.85 | HTR1A (0.68) | TDP1HTR1ACYP1A2CYP3A4MAPT | |
| SCHEMBL10968918 | 0.85 | HTR1A (0.62) | TDP1HTR1ACYP1A2CYP3A4MAPT | |
| SCHEMBL10967592 | 0.84 | HTR1A (0.54) | TDP1HTR1ACYP1A2CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0164633-A2 | Indole derivatives | MERCK PATENT GmbH (DE) | 1985-12-18 | — | — | EP | disclosed |