Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 9/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5111868 | 0.84 | MAOA (0.81) | MAOAKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL21840827 | 0.82 | MAOA (0.90) | MAOAKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL14414742 | 0.81 | CHEK1 (0.75) | MAOAKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL2812760 | 0.80 | MAOA (1.00) | MAOAKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL9261554 | 0.79 | MAOA (0.97) | MAOAKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL29539012 | 0.79 | MAOA (0.97) | MAOAKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL3954523 | 0.79 | MAOA (0.84) | MAOAKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL3151374 | 0.75 | ALDH1A1 (0.71) | MAOAKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL6263718 | 0.75 | MAOA (0.90) | MAOAKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL22321720 | 0.74 | MAOA (0.83) | MAOAKMT2AALDH1A1MEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150891-A1 | Tricyclic compounds, processes for their preparation, compositions containing such compounds and their use in medicine | THE WELLCOME FOUNDATION LIMITED (GB) | 1985-08-07 | — | — | EP | disclosed |