Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | OGA | O60502 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.43 |
| ▸ | TMIGD3 | P0DMS9 | 3/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8851160 | 0.94 | ADK (0.54) | ADKALDH1A1MEN1KMT2AOGA | |
| SCHEMBL8851335 | 0.88 | PDE4A (0.55) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10664114 | 0.86 | ADK (0.43) | ADKPIK3CDPIK3R1ADORA2AADORA1 | |
| SCHEMBL10972136 | 0.83 | ADK (0.42) | ADKPIK3CDPIK3R1ADORA2AADORA1 | |
| SCHEMBL11047372 | 0.82 | ACHE (0.49) | ADKALDH1A1ADORA2AADORA1TMIGD3 | |
| SCHEMBL9232181 | 0.80 | ADK (0.48) | ADKPIK3CDADORA2AADORA1TMIGD3 | |
| SCHEMBL10660880 | 0.80 | NPSR1 (0.43) | ADKALDH1A1ADORA2AADORA1TMIGD3 | |
| SCHEMBL10663616 | 0.80 | ALDH1A1 (0.43) | ADKALDH1A1OGAPDE4APDE4B | |
| SCHEMBL10664729 | 0.80 | ADORA2A (0.53) | ALDH1A1MEN1KMT2AADORA2AMAPT | |
| SCHEMBL11028726 | 0.79 | OGA (0.53) | ADKALDH1A1MEN1KMT2APIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618814-A | Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds | DR. KARL THOMAE GMBH (DE) | 1997-04-08 | — | — | US | disclosed |
| EP-0645390-A1 | Trisubstituted pyrimido 5,4-d pyrimidines for modulating multidrug resistance, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1995-03-29 | — | — | EP | disclosed |