Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 12/20 | 0.89 |
| ▸ | PDGFRB | P09619 | 12/20 | 0.89 |
| ▸ | FLT4 | P35916 | 11/20 | 0.89 |
| ▸ | CSF1R | P07333 | 8/20 | 0.89 |
| ▸ | KDR | P35968 | 4/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | MET | P08581 | 2/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1100121 | 0.94 | PDGFRB (1.00) | FLT3PDGFRBFLT4CSF1RKDR | |
| SCHEMBL1097792 | 0.94 | PDGFRB (0.89) | FLT3PDGFRBFLT4CSF1RKDR | |
| SCHEMBL1098263 | 0.92 | FLT3 (0.92) | FLT3PDGFRBFLT4CSF1RKDR | |
| SCHEMBL1099074 | 0.91 | FLT3 (0.84) | FLT3PDGFRBFLT4CSF1RKDR | |
| SCHEMBL1098381 | 0.90 | FLT3 (0.72) | FLT3PDGFRBFLT4CSF1RKDR | |
| SCHEMBL1098242 | 0.85 | PDGFRB (0.73) | FLT3PDGFRBFLT4CSF1RMET | |
| SCHEMBL1098493 | 0.85 | PDGFRB (0.81) | FLT3PDGFRBFLT4CSF1RKDR | |
| SCHEMBL1099237 | 0.84 | PDGFRB (0.72) | FLT3PDGFRBFLT4CSF1RKDR | |
| SCHEMBL1097920 | 0.84 | PDGFRB (0.79) | FLT3PDGFRBFLT4CSF1RKDR | |
| SCHEMBL1099446 | 0.83 | PDGFRB (0.70) | FLT3PDGFRBFLT4CSF1RKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802591-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2012-01-11 | — | — | EP | claimed |
| US-20090233924-A1 | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2009-09-17 | — | — | US | claimed |
| EP-1802591-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2007-07-04 | — | — | EP | claimed |
| WO-2006040520-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-04-20 | — | — | WO | claimed |
| US-20120165351-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2012-06-28 | — | — | US | disclosed |
| US-8153643-B2 | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2012-04-10 | — | — | US | disclosed |
| US-20090233924-A1 | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233924-A1 | Quinazoline derivatives | AQP1, PGF, F12 | FLT3 117/4885PDGFRB 700/4885FLT4 10/4885 |
| US-20120165351-A1 | QUINAZOLINE DERIVATIVES | AQP1, F12, AQP3 | FLT3 126/4885PDGFRB 1056/4885FLT4 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.