SCHEMBL10976375

SCHEMBL10976375

COC(=O)Oc1cnn(-c2c(Cl)cc(Cl)cc2Cl)c1N

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.44
SCN9A Q15858 3/20 0.38
SCN5A Q14524 2/20 0.38
SRC P12931 3/20 0.38
KDR P35968 3/20 0.38
CDK4 P11802 1/20 0.37
CCND1 P24385 1/20 0.37
GABRP O00591 1/20 0.37
GABRD O14764 1/20 0.37
GABRA1 P14867 1/20 0.37
GABRB1 P18505 1/20 0.37
GABRG2 P18507 1/20 0.37
GABRB3 P28472 1/20 0.37
GABRA5 P31644 1/20 0.37
GABRA3 P34903 1/20 0.37
GABRA2 P47869 1/20 0.37
GABRB2 P47870 1/20 0.37
GABRA4 P48169 1/20 0.37
GABRE P78334 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10972288 0.86 PKM (0.44) SCN9ASCN5ACNR1
SCHEMBL10976597 0.80 CUL4A (0.34) SCN9ASCN5ACUL4AMAPK14
SCHEMBL10972269 0.80 SCN9A (0.47) SCN9ASCN5AHTTMAPK14CNR1
SCHEMBL10344685 0.80 MAPK1 (0.55) MAPK1L3MBTL1SCN9ASCN5AGABRP
SCHEMBL6476731 0.73 MAPK1 (0.56) MAPK1L3MBTL1SRCKDRCDK4
SCHEMBL1456561 0.72 MAPK14 (0.41) SRCKDRHTTMAPK14FGFR1
SCHEMBL10717398 0.72 LMNA (0.36) MAPK1L3MBTL1SRCKDRHTT
SCHEMBL10344566 0.72 KMT2A (0.46) MAPK1SCN9ASCN5AHTT
SCHEMBL11083137 0.71 MAPK1 (0.55) MAPK1L3MBTL1SRCKDRCDK4
SCHEMBL10655728 0.71 HTT (0.67) MAPK1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0053698-B1 5-AMINO-1-PHENYLPYRAZOLE-4-CARBOXYLIC ACIDS, PROCESS FOR THEIR PREPARATION, HERBICIDES CONTAINING THEM AND THEIR USE AS HERBICIDES BASF Aktiengesellschaft (DE) 1985-01-09 EP claimed
EP-0053698-A1 5-Amino-1-phenylpyrazole-4-carboxylic acids, process for their preparation, herbicides containing them and their use as herbicides BASF Aktiengesellschaft (DE) 1982-06-16 EP claimed
EP-0053698-B1 5-AMINO-1-PHENYLPYRAZOLE-4-CARBOXYLIC ACIDS, PROCESS FOR THEIR PREPARATION, HERBICIDES CONTAINING THEM AND THEIR USE AS HERBICIDES BASF Aktiengesellschaft (DE) 1985-01-09 EP disclosed
EP-0071794-A1 5-Amino-1-phenyl-pyrazole-4-carboxylic-acid derivatives, process for their preparation and their use as herbicides BASF Aktiengesellschaft (DE) 1983-02-16 EP disclosed
EP-0053698-A1 5-Amino-1-phenylpyrazole-4-carboxylic acids, process for their preparation, herbicides containing them and their use as herbicides BASF Aktiengesellschaft (DE) 1982-06-16 EP disclosed