SCHEMBL11083137

SCHEMBL11083137

CN(C)C(=O)c1cnn(-c2c(Cl)cc(Cl)cc2Cl)c1N

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.55
L3MBTL1 Q9Y468 2/20 0.42
SRC P12931 4/20 0.41
KDR P35968 4/20 0.41
HTT P42858 1/20 0.40
SPR P35270 1/20 0.39
BTK Q06187 1/20 0.38
ALDH1A1 P00352 4/20 0.38
CDK4 P11802 1/20 0.38
CCND1 P24385 1/20 0.38
NR3C1 P04150 1/20 0.38
FGFR1 P11362 2/20 0.37
FGFR2 P21802 2/20 0.37
FGFR4 P22455 2/20 0.37
FGFR3 P22607 2/20 0.37
KMT2A Q03164 3/20 0.36
MEN1 O00255 2/20 0.36
MAPT P10636 1/20 0.36
KDM4E B2RXH2 1/20 0.36
GLA P06280 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6476731 0.82 MAPK1 (0.56) MAPK1L3MBTL1SRCKDRHTT
SCHEMBL10344685 0.81 MAPK1 (0.55) MAPK1L3MBTL1HTTALDH1A1KMT2A
SCHEMBL10365401 0.80 MAPK1 (0.51) MAPK1L3MBTL1SPRALDH1A1CDK4
SCHEMBL10655728 0.77 HTT (0.67) MAPK1HTTALDH1A1KMT2AMEN1
SCHEMBL10344566 0.73 KMT2A (0.46) MAPK1HTTALDH1A1KMT2AMEN1
SCHEMBL11077503 0.73 HTT (0.49) MAPK1L3MBTL1HTTALDH1A1KMT2A
SCHEMBL10976375 0.71 MAPK1 (0.47) MAPK1L3MBTL1SRCKDRHTT
SCHEMBL9308949 0.71 MAPK1 (0.78) MAPK1L3MBTL1SPRCDK4CCND1
SCHEMBL7229595 0.71 MAPK1 (1.00) MAPK1L3MBTL1SPRALDH1A1CDK4
SCHEMBL3816393 0.71 ALDH1A1 (0.59) HTTALDH1A1KMT2AMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4472192-A POST-AND PREEMERGENCE HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1984-09-18 US disclosed