Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 9/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11031529 | 0.87 | ACE2 (0.37) | CNR2CNR1OPRM1ACE2 | |
| SCHEMBL11183937 | 0.75 | CNR2 (0.34) | CNR2CNR1NR1I2ADORA3SLC6A3 | |
| SCHEMBL11041333 | 0.75 | CNR2 (0.34) | CNR2CNR1NR1I2ADORA3SLC6A3 | |
| SCHEMBL11367658 | 0.74 | PDE4A (0.35) | ACE2 | |
| SCHEMBL11190084 | 0.74 | PDE4A (0.35) | ACE2 | |
| SCHEMBL10976470 | 0.72 | HTR1A (0.30) | — | |
| SCHEMBL10406100 | 0.70 | CNR2 (0.42) | CNR2CNR1NR1I2ADORA3SLC6A3 | |
| SCHEMBL10406352 | 0.70 | CNR2 (0.42) | CNR2CNR1NR1I2ADORA3SLC6A3 | |
| SCHEMBL11160930 | 0.69 | PTPN1 (0.34) | — | |
| SCHEMBL11158742 | 0.69 | HTR1A (0.34) | CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0045171-B1 | 9-AMINO-1-HYDROXYOCTAHYDROBENZO(C)QUINOLINES AND DERIVATIVES THEREOF | PFIZER INC. (US) | 1985-02-13 | — | — | EP | disclosed |
| US-4351833-A | 9-Amino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives thereof as analgesics and anti-emetics | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4309545-A | ANALGESICS, TRANQUILIZERS, ANTIEMETICS, DIURETICS, ANTICONVULSANTS, ANTIDIARRHEAL, ANTITUSSIVES AND IN THE TREATMENT OF GLAUCOMA | PFIZER INC. (US) | 1982-01-05 | — | — | US | disclosed |