Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 3/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10977382 | 1.00 | OPRM1 (0.47) | OPRM1SIGMAR1HTR1AADRA1DADRA1A | |
| SCHEMBL10979584 | 0.77 | KMT2A (0.43) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL10979581 | 0.77 | KMT2A (0.43) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL10977153 | 0.74 | DRD2 (0.42) | SIGMAR1CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL10980746 | 0.74 | SIGMAR1 (0.55) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL10977151 | 0.74 | DRD2 (0.42) | SIGMAR1CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL10979574 | 0.74 | SIGMAR1 (0.55) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL10980846 | 0.73 | MAOA (0.40) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL10980578 | 0.73 | HRH3 (0.49) | OPRM1SIGMAR1ADRA1DADRA1AADRA1B | |
| SCHEMBL10980577 | 0.73 | HRH3 (0.49) | OPRM1SIGMAR1ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4496579-A | AMINATION WITH AMMONIA OR PRIMARY AMINE; ANTIDEPRESANT | GLAXO GROUP LIMITED (GB) | 1985-01-29 | — | — | US | disclosed |