Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.40 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10972776 | 0.90 | CNR1 (0.54) | ALDH1A1L3MBTL1CNR1CNR2HCAR1 | |
| SCHEMBL11374217 | 0.88 | CNR1 (0.53) | ALDH1A1L3MBTL1CNR1CNR2ALOX15 | |
| SCHEMBL11340568 | 0.87 | CNR1 (0.52) | ALDH1A1L3MBTL1CNR1CNR2THRB | |
| SCHEMBL10973770 | 0.87 | CNR1 (0.56) | ALDH1A1L3MBTL1CNR1CNR2HCAR1 | |
| SCHEMBL10979002 | 0.85 | CNR1 (0.51) | ALDH1A1CNR1CNR2HCAR1ALOX15 | |
| SCHEMBL11369431 | 0.85 | CNR1 (0.51) | ALDH1A1CNR1CNR2ALOX15THRB | |
| SCHEMBL10980011 | 0.84 | CNR1 (0.53) | ALDH1A1L3MBTL1CNR1CNR2THRB | |
| SCHEMBL11372681 | 0.83 | POLB (0.48) | ALDH1A1L3MBTL1CNR1CNR2HCAR1 | |
| SCHEMBL11368889 | 0.82 | ALDH1A1 (0.52) | ALDH1A1CNR1CNR2ALOX15THRB | |
| SCHEMBL11024730 | 0.81 | NPC1 (0.41) | ALDH1A1CNR1CNR2HCAR1SLC5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4276295-A | VASODILATORS, HYPOTENSIVE, ANTIATHEROSCLEROTIC | Ishikawa, Masayuki (JP) | 1981-06-30 | — | — | US | claimed |
| EP-0056637-B1 | 4(3H)-QUINAZOLINONE DERIVATIVES, PROCESS FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID COMPOUNDS | Ishikawa, Masayuki (JP) | 1985-07-24 | — | — | EP | disclosed |