Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27594121 | 0.89 | PDE3B (0.41) | PDE3BPDE3AP2RY12FAAHHPGD | |
| SCHEMBL10979090 | 0.82 | PDE3B (0.40) | PDE3BPDE3AP2RY12FAAHHPGD | |
| SCHEMBL28193122 | 0.81 | MBOAT4 (0.51) | HPGDTSHRMAPTALDH1A1LMNA | |
| SCHEMBL28275792 | 0.81 | LOXL2 (0.51) | PDE3BPDE3AP2RY12HPGDEPHX2 | |
| SCHEMBL10974800 | 0.77 | CYP11B1 (0.43) | PDE3BPDE3AP2RY12FAAHHPGD | |
| SCHEMBL1410550 | 0.77 | CYP4F2 (0.42) | MAPTALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL18291564 | 0.77 | POLB (0.45) | HPGDTSHRMAPTALDH1A1KDM4E | |
| SCHEMBL10978511 | 0.76 | PDE3B (0.41) | PDE3BPDE3AP2RY12TSHRMAPT | |
| SCHEMBL4832980 | 0.76 | LOXL2 (0.53) | EPHX2TSHRMAPTALDH1A1LMNA | |
| SCHEMBL22242096 | 0.75 | CYP11B1 (0.41) | TSHRALDH1A1L3MBTL1MBOAT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0068386-B1 | SUBSTITUTED IMIDAZO(1,5-A)PYRIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS | CIBA-GEIGY AG (CH) | 1985-12-18 | — | — | EP | disclosed |
| US-4470986-A | ISCHEMIA, SHOCK, THROMBOSIS | CIBA-GEIGY CORPORATION (US) | 1984-09-11 | — | — | US | disclosed |
| EP-0114572-A1 | Substituted imidazo(1,5-a)pyridines | CIBA-GEIGY AG (CH) | 1984-08-01 | — | — | EP | disclosed |
| US-4444775-A | ENZYME INHIBITORS | CIBA-GEIGY CORPORATION (US) | 1984-04-24 | — | — | US | disclosed |
| EP-0068386-A1 | Substituted imidazo(1,5-a)pyridines, process for their preparation and pharmaceutical preparations containing these compounds | CIBA-GEIGY AG (CH) | 1983-01-05 | — | — | EP | disclosed |