Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.39 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.39 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10974338 | 0.81 | MAPT (0.41) | ALDH1A1RAB9AMAPTSMN1; SMN2GSK3B | |
| SCHEMBL5523498 | 0.76 | NPC1 (0.47) | ALDH1A1RAB9AMAPTSMN1; SMN2GSK3B | |
| Hydrochloric Acid SCHEMBL5850214 | 0.75 | RAB9A (0.46) | ALDH1A1RAB9AMAPTSMN1; SMN2GSK3B | |
| SCHEMBL10986706 | 0.71 | CTNNB1 (0.44) | ALDH1A1RAB9AMAPTSMN1; SMN2GSK3B | |
| Bromide SCHEMBL10981550 | 0.70 | CTNNB1 (0.43) | ALDH1A1RAB9AMAPTSMN1; SMN2GSK3B | |
| SCHEMBL5849864 | 0.67 | RAB9A (0.47) | ALDH1A1RAB9AMAPTSMN1; SMN2GSK3B | |
| SCHEMBL4968860 | 0.66 | GAA (0.61) | ALDH1A1RAB9AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL31158393 | 0.65 | ADORA3 (0.49) | ALDH1A1RAB9AMAPTSMN1; SMN2GSK3B | |
| Hydrochloric Acid SCHEMBL5851393 | 0.65 | GAA (0.59) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2936987 | 0.64 | GSK3B (0.52) | ALDH1A1RAB9AMAPTSMN1; SMN2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0033195-B1 | PYRIMIDINE-2-SULPHIDES AND THEIR S-OXIDES FOR USE IN MEDICINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PROCESSES FOR THEIR PREPARATION AND SUCH COMPOUNDS WHEN NOVEL PER SE | NYEGAARD & CO. A/S (NO) | 1985-12-04 | — | — | EP | disclosed |
| US-4423047-A | INHIBITING ABNORMAL CELL PROLIFERATION | NYEGAARD & CO. A/S (NO) | 1983-12-27 | — | — | US | disclosed |
| EP-0033195-A1 | Pyrimidine-2-sulphides and their S-oxides for use in medicine, pharmaceutical compositions containing them, processes for their preparation and such compounds when novel per se | NYEGAARD & CO. A/S (NO) | 1981-08-05 | — | — | EP | disclosed |