Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 1/20 | 0.52 |
| ▸ | HINT1 | P49773 | 5/20 | 0.50 |
| ▸ | TGM2 | P21980 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.48 |
| ▸ | KRAS | P01116 | 6/20 | 0.47 |
| ▸ | GSK3A | P49840 | 2/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoramidic Acid SCHEMBL112033 | 0.96 | NT5E (0.53) | NT5EHINT1TGM2TAAR1HPRT1 | |
| Phosphoramidic Acid SCHEMBL108470 | 0.91 | NT5E (0.54) | NT5EHINT1TGM2TAAR1KRAS | |
| Phosphoramidic Acid SCHEMBL111677 | 0.86 | POLB (0.52) | NT5EHPRT1 | |
| Phosphoramidic Acid SCHEMBL111868 | 0.84 | GNMT (0.56) | NT5E | |
| Phosphoramidic Acid SCHEMBL112292 | 0.82 | POLB (0.53) | NT5ETGM2TAAR1HPRT1KRAS | |
| SCHEMBL22636005 | 0.80 | NT5E (0.62) | NT5EHINT1TGM2TAAR1KRAS | |
| SCHEMBL22498538 | 0.80 | NT5E (0.62) | NT5EHINT1TGM2TAAR1KRAS | |
| SCHEMBL7535718 | 0.79 | HINT1 (0.58) | NT5EHINT1TGM2TAAR1KRAS | |
| Phosphoramidic Acid SCHEMBL109493 | 0.79 | QARS1 (0.56) | — | |
| SCHEMBL11163143 | 0.79 | HINT1 (0.58) | NT5EHINT1TGM2TAAR1KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108533-A1 | NOVEL PHOSPHATE MODIFIED NUCLEOSIDES USEFUL AS SUBSTRATES FOR POLYMERASES AND AS ANTIVIRAL AGENTS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D (BE) | 2012-05-03 | — | — | US | disclosed |
| EP-2424874-A1 | NOVEL PHOSPHATE MODIFIED NUCLEOSIDES USEFUL AS SUBSTRATES FOR POLYMERASES AND AS ANTIVIRAL ANGENTS | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010125200-A1 | NOVEL PHOSPHATE MODIFIED NUCLEOSIDES USEFUL AS SUBSTRATES FOR POLYMERASES AND AS ANTIVIRAL ANGENTS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2010-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108533-A1 | NOVEL PHOSPHATE MODIFIED NUCLEOSIDES USEFUL AS SUBSTRATES FOR POLYMERASES AND AS ANTIVIRAL AGENTS | PNP, TYMP, MTAP | NT5E 253/4885HINT1 119/4885TGM2 4080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.