GNMT — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL22323629	0.56	4/20
SCHEMBL22343635	0.44	4/20
SCHEMBL6901855	0.80	3/20
SCHEMBL9550942	0.80	3/20
SCHEMBL17551942	0.80	3/20
SCHEMBL19434095	0.80	3/20
SCHEMBL6899844	0.77	3/20
SCHEMBL6900840	0.77	3/20
SCHEMBL6907796	0.76	3/20
SCHEMBL6902821	0.74	3/20
SCHEMBL6907266	0.74	3/20
SCHEMBL7054700	0.74	3/20
SCHEMBL7054701	0.74	3/20
SCHEMBL7154290	0.73	3/20
SCHEMBL6906701	0.73	3/20
SCHEMBL29598517	0.71	3/20
SCHEMBL6900787	0.69	3/20
SCHEMBL6904454	0.68	3/20
SCHEMBL6907808	0.68	3/20
SCHEMBL19302866	0.60	3/20

Clinical trials — most relevant to GNMT by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Trial of CM-AT in Children With Autism With All Levels of FCT (The Blum Study)	PHASE3	COMPLETED
Guanidinoacetic Acid (GAA) Administration in Physically Active Men and Women	PHASE1/PHASE2	COMPLETED
Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor	PHASE1/PHASE2	NOT_YET_RECRUITING
Treatment With Azacitidine of Recurrent Gliomas With IDH1/2 Mutation	PHASE2	UNKNOWN
Sarcosine Preventive Therapy for Individuals At High Risk for Schizophrenia	PHASE2	WITHDRAWN
Neurobiology of a Mutation in Glycine Metabolism in Psychotic Disorders	PHASE2	COMPLETED
NIVOLUMAB Plus IPILIMUMAB and TEMOZOLOMIDE in Microsatellite Stable, MGMT Silenced Metastatic Colorectal Cancer	PHASE2	COMPLETED
Temozolomide Monotherapy or in Combination With Olaparib in Patients With Triple Negative Breast Cancer (TNBC)	PHASE2	NOT_YET_RECRUITING
N-methyl Glycine (Sarcosine) for the Treatment of Obsessive Compulsive Disorder (OCD)	PHASE2	COMPLETED
Phase I Trial of 4'-Thio-2'-Deoxycytidine (TdCyd) in Patients With Advanced Solid Tumors	PHASE1	COMPLETED
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer	nan	UNKNOWN
DNA Methylation and Arsenic-associated Urothelial Carcinoma	nan	UNKNOWN
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients	nan	COMPLETED
In Vivo Assessment of Histamine Pharmacodynamics	nan	WITHDRAWN
The Impact of Pharmacological and Electric Modulation of NMDA Pathway on the Cognitive Flexibility and Volitional Movement Preparation in Patients With Parkinson's Disease	nan	COMPLETED
Efficacy of Essential Phospholipid Versus Betaine HCL/L-Glutamic Acid in MAFLD	nan	NOT_YET_RECRUITING
Vancomycin Associated Red Man Syndrome (RMS)	nan	COMPLETED
Acute Glycine Pharmacodynamic Study	nan	COMPLETED
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients.	nan	COMPLETED
Human Requirements for the Nutrient Choline	nan	COMPLETED
Melatonin in Pregnancy	nan	COMPLETED
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione	nan	COMPLETED
The Molecular Pathogenesis Study of Cataract	nan	UNKNOWN
Studying The Role of Key Epigenetic Mediators in Breast Cancer Patients	nan	RECRUITING
Choline Dose Ranging in Postmenopausal Women	nan	COMPLETED
Adenosylmethionine Metabolism in Human Inflammation	nan	UNKNOWN
Neural Response to Catecholamine Depletion in Subjects Suffering From Bulimia Nervosa in Their Past and Healthy Controls	nan	SUSPENDED
Impact Of Choline in Patients With NAFLD	nan	UNKNOWN
Estrogen Receptor 1 Gene Polymorphism Frequency in Fibromyalgia Syndrome	nan	COMPLETED
DNA Methylation and Autoimmune Thyroid Diseases	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GNMT binder may also engage these)

Protein	Name	Similarity
Q29513	—	0.999	Q29513 →
P13255	—	0.999	P13255 →
Q9QXF8	—	0.998	Q9QXF8 →
Q29555	—	0.997	Q29555 →
P10868	—	0.965	P10868 →
O35969	—	0.963	O35969 →
Q6NYU2	—	0.961	Q6NYU2 →
EPM2A	Laforin	0.960	landscape →
Q5IH13	—	0.959	Q5IH13 →
A3KFX0	—	0.958	A3KFX0 →
Q14353	—	0.957	Q14353 →
Q80YV4	—	0.957	Q80YV4 →
Q6DFV5	—	0.956	Q6DFV5 →
Q2TBQ3	—	0.955	Q2TBQ3 →
Q5RAF1	—	0.955	Q5RAF1 →
A5HK05	—	0.954	A5HK05 →
Q9BXI3	—	0.954	Q9BXI3 →
P11716	—	0.954	P11716 →
BPHL	Serine hydrolase BPHL	0.954	landscape →
Q6P4H8	—	0.953	Q6P4H8 →
Q9UK99	—	0.953	Q9UK99 →
Q5F480	—	0.952	Q5F480 →
Q8K2D3	—	0.952	Q8K2D3 →
A6H7H7	—	0.952	A6H7H7 →
Q9WUA5	—	0.952	Q9WUA5 →
Q0V8R7	—	0.952	Q0V8R7 →
Q5RDU9	—	0.951	Q5RDU9 →
Q4R3J7	—	0.951	Q4R3J7 →
Q5FVD6	—	0.951	Q5FVD6 →
Q8BGZ3	—	0.951	Q8BGZ3 →