Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 13/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1098507 | 0.90 | TRPM8 (0.57) | TRPM8PTGDR2PTPN7DUSP3P2RX7 | |
| SCHEMBL1099941 | 0.89 | TRPM8 (0.56) | TRPM8PTGDR2PTPN7DUSP3P2RX7 | |
| SCHEMBL1100469 | 0.88 | TRPM8 (0.55) | TRPM8PTPN7DUSP3 | |
| SCHEMBL1101011 | 0.87 | TRPM8 (0.55) | TRPM8PTGDR2PTPN7DUSP3P2RX7 | |
| SCHEMBL1099555 | 0.87 | TRPM8 (0.54) | TRPM8PTGDR2PTPN7DUSP3P2RX7 | |
| SCHEMBL1099352 | 0.86 | TRPM8 (0.54) | TRPM8PTGDR2PTPN7DUSP3 | |
| SCHEMBL1098849 | 0.86 | TRPM8 (0.68) | TRPM8L3MBTL1 | |
| SCHEMBL1099349 | 0.84 | TRPM8 (0.60) | TRPM8L3MBTL1PTPN7DUSP3 | |
| SCHEMBL1098416 | 0.84 | TRPM8 (0.56) | TRPM8TSHRALDH1A1POLBPTPN7 | |
| SCHEMBL1101417 | 0.83 | TRPM8 (0.64) | TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153682-B2 | Sulfonamides as TRPM8 modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2012-04-10 | — | — | US | disclosed |
| US-20090264474-A1 | SULFONAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264474-A1 | SULFONAMIDES AS TRPM8 MODULATORS | TRPM8, TRPM5, TRPM2 | TRPM8 1/4885L3MBTL1 3261/4885TSHR 1373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.