Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 3/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.46 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.46 |
| ▸ | NMBR | P28336 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 7/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10980392 | 1.00 | REN (0.54) | RENCASP3CTSBCTSKPSMB1 | |
| SCHEMBL10636529 | 0.92 | REN (0.58) | RENCASP3CTSBCTSKPSMB1 | |
| SCHEMBL10633366 | 0.92 | REN (0.58) | RENCASP3CTSBCTSKPSMB1 | |
| SCHEMBL10981168 | 0.92 | REN (0.58) | RENCASP3CTSBCTSKPSMB1 | |
| SCHEMBL10976366 | 0.92 | REN (0.58) | RENCASP3CTSBCTSKPSMB1 | |
| SCHEMBL10978085 | 0.91 | REN (0.63) | RENCASP3CTSBCTSKNMBR | |
| SCHEMBL10981144 | 0.90 | PSMB1 (0.52) | RENCTSBCTSKPSMB1PSMB5 | |
| SCHEMBL10981150 | 0.90 | PSMB1 (0.52) | RENCTSBCTSKPSMB1PSMB5 | |
| SCHEMBL10633448 | 0.90 | REN (0.56) | RENCASP3CTSBCTSKPSMB1 | |
| SCHEMBL10636517 | 0.89 | REN (0.56) | RENCASP3CTSBCTSKPSMB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4548926-A | RENIN INHIBITOR | SANKYO COMPANY LIMITED (JP) | 1985-10-22 | — | — | US | disclosed |
| EP-0128762-A2 | New hypotensive peptides, their preparation and their use | SANKYO COMPANY LIMITED (JP) | 1984-12-19 | — | — | EP | disclosed |