Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.36 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8802556 | 0.97 | ACHE (0.44) | ACHEMEN1KMT2ATDP1PHGDH | |
| SCHEMBL1629925 | 0.90 | PHGDH (0.42) | ACHEMEN1KMT2ATDP1PHGDH | |
| SCHEMBL726800 | 0.86 | PHGDH (0.33) | ACHEMEN1KMT2ATDP1PHGDH | |
| SCHEMBL3301628 | 0.84 | ACHE (0.35) | ACHEMEN1KMT2ATDP1PHGDH | |
| Hydrochloric Acid SCHEMBL7497886 | 0.82 | ACHE (0.34) | ACHEPHGDHMGLLHRH3ALDH1A1 | |
| SCHEMBL727807 | 0.82 | ALDH1A1 (0.37) | ACHEMEN1KMT2APHGDHMGLL | |
| Bromide SCHEMBL8688240 | 0.82 | ACHE (0.34) | ACHEPHGDHMGLLHRH3ALDH1A1 | |
| SCHEMBL8196122 | 0.78 | ACHE (0.32) | ACHE | |
| SCHEMBL19563524 | 0.77 | CARM1 (0.38) | ACHEMEN1KMT2APHGDHMGLL | |
| SCHEMBL8151598 | 0.75 | ACHE (0.31) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4491586-A | Amine derivatives | GLAXO GROUP LIMITED (GB) | 1985-01-01 | — | — | US | disclosed |
| EP-0029306-B1 | AMINOALKYL COMPOUNDS, THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1984-07-25 | — | — | EP | disclosed |
| EP-0029306-A1 | Aminoalkyl compounds, their production and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1981-05-27 | — | — | EP | disclosed |
| US-4064347-A | Bis-basic ketones of fluorene and fluorenone | RICHARDSON-MERRELL INC. (US) | 1977-12-20 | — | — | US | disclosed |