Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 9/20 | 0.46 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | CTSV | O60911 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10990305 | 1.00 | KDM5A (0.47) | KDM5AKDM5BDHODHGPR84KAT8 | |
| SCHEMBL10981682 | 1.00 | KDM5A (0.47) | KDM5AKDM5BDHODHGPR84KAT8 | |
| SCHEMBL27285942 | 0.94 | KDM5A (0.49) | KDM5AKDM5BDHODHHCAR2PARP1 | |
| SCHEMBL7416444 | 0.86 | MTNR1A (0.46) | GPR84PARP1CTSVCTSL | |
| SCHEMBL13492005 | 0.83 | DHODH (0.54) | KDM5AKDM5BDHODHPARP1 | |
| SCHEMBL27628586 | 0.81 | CTSV (0.50) | GPR84KAT8HCAR2PPARAPARP1 | |
| SCHEMBL7412802 | 0.80 | MTNR1A (0.48) | PARP1 | |
| SCHEMBL10978966 | 0.78 | CTSV (0.59) | GPR84KAT8HCAR2PPARAPARP1 | |
| SCHEMBL10978475 | 0.78 | CTSV (0.59) | GPR84KAT8HCAR2PPARAPARP1 | |
| SCHEMBL10983500 | 0.78 | CTSV (0.59) | GPR84KAT8HCAR2PPARAPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4493843-A | Indole and indoline carboxylic acid compounds and method of use | MAY & BAKER LIMITED (GB) | 1985-01-15 | — | — | US | disclosed |
| EP-0042298-B1 | INDOLE AND INDOLINE DERIVATIVES | MAY & BAKER LIMITED (GB) | 1984-09-12 | — | — | EP | disclosed |
| EP-0042298-A1 | Indole and indoline derivatives | MAY & BAKER LIMITED (GB) | 1981-12-23 | — | — | EP | disclosed |