Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11860380 | 0.82 | KIF11 (0.49) | KMT2AMEN1CRHBPCRHR2NPC1 | |
| SCHEMBL11860377 | 0.82 | KIF11 (0.49) | KMT2AMEN1CRHBPCRHR2NPC1 | |
| SCHEMBL10988423 | 0.78 | KMT2A (0.41) | KMT2AMEN1CRHBPCRHR2NPC1 | |
| SCHEMBL2333106 | 0.76 | ALDH1A1 (0.62) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28403191 | 0.75 | IDO1 (0.55) | SMN1; SMN2ALDH1A1HTTGAA | |
| SCHEMBL11430769 | 0.74 | ACE (0.54) | SMN1; SMN2ALDH1A1GAAPOLB | |
| SCHEMBL11562418 | 0.74 | PPARA (0.65) | ALDH1A1GAAITGA4ITGB7 | |
| SCHEMBL11327876 | 0.74 | PPARA (0.65) | ALDH1A1GAAITGA4ITGB7 | |
| SCHEMBL7305729 | 0.72 | KIF11 (0.44) | KMT2ASMN1; SMN2ALDH1A1HPGDHTT | |
| SCHEMBL10993383 | 0.72 | TSHR (0.39) | KMT2AMEN1CRHBPCRHR2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4499287-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1985-02-12 | — | — | US | disclosed |
| US-4456761-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1984-06-26 | — | — | US | disclosed |
| US-4356182-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-10-26 | — | — | US | disclosed |
| US-4316905-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-02-23 | — | — | US | disclosed |
| US-4311697-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-01-19 | — | — | US | disclosed |
| US-4291040-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1981-09-22 | — | — | US | disclosed |