Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | POLA1 | P09884 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11020679 | 0.83 | ATF1 (0.41) | CYP2D6CYP2C19KMT2APOLA1 | |
| SCHEMBL11023223 | 0.81 | CYP2D6 (0.34) | CYP2D6CYP2C19KMT2A | |
| SCHEMBL15942896 | 0.76 | CYP2D6 (0.51) | CYP2D6CYP2C19KMT2APOLA1MAPT | |
| SCHEMBL10988809 | 0.75 | MAPT (0.51) | CYP2D6CYP2C19KMT2APOLA1MAPT | |
| SCHEMBL7171477 | 0.74 | CYP2D6 (0.56) | CYP2D6CYP2C19KMT2APOLA1MAPT | |
| SCHEMBL11022815 | 0.72 | S1PR2 (0.38) | CYP2D6CYP2C19KMT2A | |
| SCHEMBL1576582 | 0.72 | NUDT1 (0.55) | CYP2D6CYP2C19KMT2APOLA1MAPT | |
| SCHEMBL11018763 | 0.70 | MAPT (0.41) | CYP2D6CYP2C19KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL3804329 | 0.70 | HSP90AA1 (0.47) | CYP2D6CYP2C19KMT2APOLA1MAPT | |
| SCHEMBL11024801 | 0.70 | NUDT1 (0.37) | CYP2D6CYP2C19KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0062439-B1 | GUANIDINOPYRIMIDINES | SMITHKLINE BECKMAN CORPORATION (US) | 1985-03-20 | — | — | EP | claimed |
| EP-0062439-A1 | Guanidinopyrimidines | SMITHKLINE BECKMAN CORPORATION (US) | 1982-10-13 | — | — | EP | claimed |
| US-4336254-A | Guanidinopyrimidine compounds, compositions and method of using as a diuretic | SMITHKLINE CORPORATION (US) | 1982-06-22 | — | — | US | claimed |
| US-20090194124-A1 | Hair Shaping Kit and Process Comprising at Least One Non-Hydroxide Imine | MALLE GERARD | 2009-08-06 | — | — | US | disclosed |
| US-20090139537-A1 | HAIR RELAXING COMPOSITION COMPRISING AT LEAST ONE NON-HYDROXIDE IMINE | L'OREAL S.A. | 2009-06-04 | — | — | US | disclosed |
| US-20050136017-A1 | Cosmetic containing an imine reactive with the cystines of keratin fibers via a beta-elimination reaction to produce dehydroalanine and lead to formation of lanthionine in a medium free of polyhydroxylated alkane; guanidine and/or amidine imines such as dimethylguanidine; noncaustic for use on hair, skin | L'OREAL S.A. (FR) | 2005-06-23 | — | — | US | disclosed |
| US-20050129645-A1 | Hair shaping composition comprising at least one non-hydroxide imine | L'OREAL | 2005-06-16 | — | — | US | disclosed |
| EP-1532963-A1 | Composition for straightening the hair comprising at least one imine not being an hydroxide | L'OREAL (FR) | 2005-05-25 | — | — | EP | disclosed |
| EP-1532960-A1 | Hair styling composition containing a non-hydroxide imine | L'OREAL (FR) | 2005-05-25 | — | — | EP | disclosed |
| EP-0062439-B1 | GUANIDINOPYRIMIDINES | SMITHKLINE BECKMAN CORPORATION (US) | 1985-03-20 | — | — | EP | disclosed |
| EP-0062439-A1 | Guanidinopyrimidines | SMITHKLINE BECKMAN CORPORATION (US) | 1982-10-13 | — | — | EP | disclosed |
| US-4336254-A | Guanidinopyrimidine compounds, compositions and method of using as a diuretic | SMITHKLINE CORPORATION (US) | 1982-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090139537-A1 | HAIR RELAXING COMPOSITION COMPRISING AT LEAST ONE NON-HYDROXIDE IMINE | KRT18, INMT, INHA | CYP2D6 3528/4885CYP2C19 2598/4885KMT2A 322/4885 |
| US-20090194124-A1 | Hair Shaping Kit and Process Comprising at Least One Non-Hydroxide Imine | KRT18, KIT, PRDM7 | CYP2D6 3530/4885CYP2C19 2140/4885KMT2A 555/4885 |
| US-20050129645-A1 | Hair shaping composition comprising at least one non-hydroxide imine | KRT18, INHA, H1-5 | CYP2D6 3645/4885CYP2C19 2413/4885KMT2A 949/4885 |
| US-20050136017-A1 | Cosmetic containing an imine reactive with the cystines of keratin fibers via a beta-elimination reaction to produce dehydroalanine and lead to formation of lanthionine in a medium free of polyhydroxylated alkane; guanidine and/or amidine imines such as dimethylguanidine; noncaustic for use on hair, skin | BHMT, KRT18, INMT | CYP2D6 2901/4885CYP2C19 2856/4885KMT2A 665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.