Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.63 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 7/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | HCK | P08631 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10992189 | 1.00 | GRM5 (0.63) | GRM5PDK1PDK2PDK3PDK4 | |
| SCHEMBL10989017 | 0.93 | GRM5 (0.68) | GRM5PDK1PDK2PDK3PDK4 | |
| SCHEMBL10989034 | 0.93 | GRM5 (0.68) | GRM5PDK1PDK2PDK3PDK4 | |
| SCHEMBL10993124 | 0.91 | GRM5 (0.62) | GRM5GAANPC1RAB9APOLB | |
| SCHEMBL10993126 | 0.91 | GRM5 (0.62) | GRM5GAANPC1RAB9APOLB | |
| SCHEMBL10992614 | 0.87 | GRM5 (0.61) | GRM5GAANPC1RAB9A | |
| SCHEMBL10991224 | 0.85 | GRM5 (0.59) | GRM5GAANPC1RAB9APOLB | |
| SCHEMBL10998692 | 0.85 | GRM5 (0.59) | GRM5PDK1PDK2PDK3PDK4 | |
| SCHEMBL10994165 | 0.85 | GRM5 (0.46) | GRM5PDK1PDK2PDK3PDK4 | |
| SCHEMBL10997158 | 0.85 | GRM5 (0.56) | GRM5RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4542144-A | EPILEPSY | MCNEILAB INC. (US) | 1985-09-17 | — | — | US | claimed |
| US-4542144-A | EPILEPSY | MCNEILAB INC. (US) | 1985-09-17 | — | — | US | disclosed |