Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11740117 | 0.88 | TP53 (0.39) | MAPTKDM4EL3MBTL1TP53SMN1; SMN2 | |
| SCHEMBL11733170 | 0.87 | TP53 (0.37) | MAPTKDM4EL3MBTL1TP53SMN1; SMN2 | |
| SCHEMBL11734966 | 0.86 | SMN1; SMN2 (0.44) | MAPTKDM4EL3MBTL1TP53SMN1; SMN2 | |
| SCHEMBL11735893 | 0.86 | SMN1; SMN2 (0.50) | MAPTKDM4EL3MBTL1TP53SMN1; SMN2 | |
| SCHEMBL11736358 | 0.86 | KDM4E (0.41) | MAPTKDM4EL3MBTL1TP53SMN1; SMN2 | |
| SCHEMBL11729614 | 0.86 | KDM4E (0.48) | MAPTKDM4EL3MBTL1TP53SMN1; SMN2 | |
| SCHEMBL11729010 | 0.86 | KDM4E (0.43) | MAPTKDM4EL3MBTL1TP53SMN1; SMN2 | |
| SCHEMBL11384281 | 0.84 | ACHE (0.35) | MAPTKDM4EL3MBTL1TP53SMN1; SMN2 | |
| SCHEMBL11736073 | 0.84 | ALDH1A1 (0.38) | MAPTKDM4EL3MBTL1TP53SMN1; SMN2 | |
| SCHEMBL11732938 | 0.83 | TP53 (0.51) | MAPTKDM4ETP53SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4535081-A | Antiallergic and antiulcer 1-oxo-1H-thiazolo[3,2-a]pyrimidine-2-carboxamides and intermediates therefor | PFIZER INC. (US) | 1985-08-13 | — | — | US | disclosed |
| US-4491587-A | ANTIALLERGENS, ANTIHISTAMINES, MUSCLE RELAXANTS/ INSULATING POWDER BLANKET ABOVD THE MELT WITH HEAT GENERATED IN THE MELT BY ELECTRIC CURRENT; LOWER TEMPERATURE | MEAD JOHNSON & COMPANY (US) | 1985-01-01 | — | — | US | disclosed |
| US-4457932-A | GASTROINTESTINAL DISORDERS | BRISTOL-MYERS COMPANY (US) | 1984-07-03 | — | — | US | disclosed |
| US-4423048-A | Antiallergic and antiulcer 1-oxo-1H-thiazolo[3,2-a]pyrimidine-2-carboxamides and intermediates therefor | PFIZER INC. (US) | 1983-12-27 | — | — | US | disclosed |
| US-4223031-A | ANTIALLERGENS, ANTIHISTAMINES, BRONCHODILATOR AGENTS, HYPERSENSITIVITY | MEAD JOHNSON & COMPANY (US) | 1980-09-16 | — | — | US | disclosed |
| US-4041163-A | N-(5-Tetrazolyl)-4-oxo-4H-pyrimido(2,1-b)benzothiazole-3-carboxamide antiallergy agents | PFIZER INC. (US) | 1977-08-09 | — | — | US | disclosed |
| US-4041163-A | N-(5-Tetrazolyl)-4-oxo-4H-pyrimido(2,1-b)benzothiazole-3-carboxamide antiallergy agents | PFIZER INC. (US) | 1977-08-09 | — | — | US | disclosed |