Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 2/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11369773 | 0.90 | NAMPT (0.44) | NAMPTKMT2AALDH1A1MEN1LMNA | |
| SCHEMBL27352286 | 0.81 | L3MBTL1 (0.50) | KMT2AALDH1A1MEN1GAACYP4F2 | |
| SCHEMBL11000781 | 0.81 | LOXL2 (0.42) | NAMPTKMT2AALDH1A1MEN1LMNA | |
| SCHEMBL2412884 | 0.79 | CYP4F2 (0.67) | NAMPTKMT2AALDH1A1MEN1LMNA | |
| SCHEMBL27207879 | 0.79 | NAMPT (0.49) | NAMPTKMT2AALDH1A1MEN1LMNA | |
| SCHEMBL11272466 | 0.79 | KMT2A (0.45) | KMT2AALDH1A1MEN1LMNAGAA | |
| Hydrochloric Acid SCHEMBL27207834 | 0.77 | NAMPT (0.48) | NAMPTKMT2AALDH1A1MEN1LMNA | |
| SCHEMBL11270504 | 0.77 | F2RL1 (0.53) | KMT2AALDH1A1LMNAPOLB | |
| SCHEMBL10996124 | 0.75 | LOXL2 (0.46) | NAMPTKMT2AALDH1A1LMNALOXL2 | |
| SCHEMBL27469498 | 0.72 | ALOX5 (0.56) | NAMPTKMT2AALDH1A1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4535084-A | ANTIARTHRITIC, ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1985-08-13 | — | — | US | disclosed |
| US-4246263-A | ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1981-01-20 | — | — | US | disclosed |