Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | LTA4H | P09960 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11007885 | 0.96 | KDM4E (0.52) | KDM4ESMN1; SMN2LTA4HALDH1A1CACNA1H | |
| Oxalic Acid SCHEMBL10988553 | 0.88 | KDM4E (0.46) | KDM4ESMN1; SMN2LTA4HPOLBALDH1A1 | |
| Oxalic Acid SCHEMBL10988556 | 0.88 | KDM4E (0.46) | KDM4ESMN1; SMN2LTA4HPOLBALDH1A1 | |
| SCHEMBL10923693 | 0.87 | LTA4H (0.51) | KDM4ESMN1; SMN2LTA4HPOLBALDH1A1 | |
| SCHEMBL11014986 | 0.85 | CYP1A2 (0.47) | KDM4ESMN1; SMN2LTA4HPOLBALDH1A1 | |
| SCHEMBL11015638 | 0.85 | HRH3 (0.55) | KDM4EPOLBALDH1A1HRH3MEN1 | |
| SCHEMBL10926336 | 0.85 | ALDH1A1 (0.45) | KDM4ESMN1; SMN2LTA4HPOLBALDH1A1 | |
| SCHEMBL10921101 | 0.84 | ALDH1A1 (0.50) | POLBALDH1A1CACNA1BHRH3 | |
| SCHEMBL10926525 | 0.83 | MEN1 (0.44) | KDM4ESMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL11009859 | 0.83 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1CACNA1HCACNA1BRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4558155-A | N-(Aryloxyalkyl)-N'-(aminoalkyl)thioureas | A. H. ROBINS COMPANY, INCORPORATED (US) | 1985-12-10 | — | — | US | disclosed |
| US-4500529-A | ANTIARRHYTHMIA AGENT | A. H. ROBINS COMPANY, INCORPORATED (US) | 1985-02-19 | — | — | US | disclosed |