1-Methylxanthine

1-Methylxanthine

SCHEMBL10996

Cn1c(=O)[nH]c2nc[nH]c2c1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2B P29275 9/20 1.00
ADORA2A P29274 6/20 1.00
ADORA3 P0DMS8 7/20 0.64
PDE4A P27815 4/20 0.64
PDE4B Q07343 4/20 0.64
PDE4C Q08493 4/20 0.64
PDE4D Q08499 4/20 0.64
ATAD2 Q6PL18 1/20 0.51
PIK3CD O00329 1/20 0.50
ALPL P05186 1/20 0.50
TMIGD3 P0DMS9 1/20 0.50
ADORA1 P30542 1/20 0.50
CYP2C19 P33261 1/20 0.50
HIF1A Q16665 1/20 0.50
ALDH1A1 P00352 1/20 0.50
LMNA P02545 1/20 0.50
CYP3A4 P08684 1/20 0.50
MAPT P10636 1/20 0.50
TSHR P16473 1/20 0.50
BLM P54132 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
1-Methylxanthine SCHEMBL27529726 0.98 ADORA2B (0.96) ADORA2BADORA2AADORA3PDE4APDE4B
1-Methylxanthine SCHEMBL9682658 0.98 ADORA2B (0.96) ADORA2BADORA2AADORA3PDE4APDE4B
1-Methylxanthine SCHEMBL28309011 0.98 ADORA2B (0.96) ADORA2BADORA2AADORA3PDE4APDE4B
1-Methylxanthine SCHEMBL28460409 0.92 ADORA2B (0.84) ADORA2BADORA2AADORA3PDE4APDE4B
1-Methylxanthine SCHEMBL29001829 0.89 ADORA2B (0.79) ADORA2BADORA2AADORA3PDE4APDE4B
1-Methylxanthine SCHEMBL16859909 0.89 ADORA2B (0.79) ADORA2BADORA2AADORA3PDE4APDE4B
1-Methylxanthine SCHEMBL7270651 0.88 ADORA2B (0.77) ADORA2BADORA2AADORA3PDE4APDE4B
3-Methylxanthine SCHEMBL1892894 0.88 ADORA2B (0.77) ADORA2BADORA2AADORA3PDE4APDE4B
Theophylline Anhydrous SCHEMBL1128138 0.88 ADORA2A (0.77) ADORA2BADORA2AADORA3PDE4APDE4B
1-Methylxanthine SCHEMBL27663813 0.88 ADORA2B (0.77) ADORA2BADORA2AADORA3PDE4APDE4B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 16622 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4747263-A1 LIPID NANOPARTICLES AND USES THEREOF University of Connecticut (US) 2026-05-27 EP claimed
EP-4728052-A1 SYSTEMS AND METHODS OF CELL TRANSPORT AT AMBIENT TEMPERATURE Bedford Research Foundation (US) 2026-04-22 EP claimed
EP-4363043-B1 COMPOSITIONS FOR USE IN METHODS FOR INCREASING CANCER CELL SENSITIVITY TO ALTERNATING ELECTRIC FIELDS NOVOCURE GMBH (CH) 2026-04-22 EP claimed
EP-4719373-A1 PHOTODYNAMIC THERAPY COMBINATIONS FOR IMPROVEMENT OF ACTINIC KERATOSIS, ACNE AND BASAL CELL CARCINOMA Alexandroff, Anton (GB) 2026-04-08 EP claimed
US-12594421-B2 Compositions and methods for increasing cancer cell sensitivity to alternating electric fields NOVOCURE GMBH (CH) 2026-04-07 US claimed
EP-3521419-B1 METHOD FOR PRODUCING BROWN ADIPOCYTES AND COMPOSITION KYOTO PREFECTURAL PUBLIC UNIV CORP (JP) 2026-03-18 EP claimed
US-20260060970-A1 Use of a Therapeutic Agent with Phosphodiesterase-7 Inhibitory Activity for the Treatment and Prevention of Diseases Associated with Chronic Fatigue, Exhaustion and/or Exertional Intolerance MITODICURE GMBH (DE) 2026-03-05 US claimed
US-20260062414-A1 NOVEL COCRYSTALS OF METHYLXANTHINES, THEIR POLYMORPHS AND PROCESS THEREOF FERTIS INDIA PVT LTD (IN) 2026-03-05 US claimed
US-20260060949-A1 METHOD FOR TREATING DAMAGE INDUCED BY SLEEP DEPRIVATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2026-03-05 US claimed
EP-4696298-A2 PERSONAL CLEANSING COMPOSITION Byrne, Daniel (IE) 2026-02-18 EP claimed
EP-0167566-A1 ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING XANTHINES AND METHODS OF USING SAME SUNSHINE, Abraham (US) 1986-01-15 EP claimed
US-4562194-A BENZOPHENONE COMPOUND IN COMBINATION WITH 3-ISOBUTYL-1-METHYLANTHINE WARNER-LAMBERT COMPANY (US) 1985-12-31 US claimed
EP-0165308-A1 ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING XANTHINES AND METHODS OF USING SAME. RICHARDSON VICKS INC (US) 1985-12-27 EP claimed
US-4558051-A Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same RICHARDSON-VICKS, INC. (US) 1985-12-10 US claimed
WO-1985002540-A1 ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING XANTHINES AND METHODS OF USING SAME RICHARDSON-VICKS, INC. (US) 1985-06-20 WO claimed
WO-1985002542-A1 ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING XANTHINES AND METHODS OF USING SAME SUNSHINE ABRAHAM 1985-06-20 WO claimed
US-4390532-A MUCOPOLYSACCHARIDES, SHIN DISORDERS DR. CARL HAHN, G.M.B.H. (DE) 1983-06-28 US claimed
US-4364922-A ATRIOVENTRICULAR CONDUCTION BLOCK UNIVERSITY OF VIRGINIA ALUMNI PATENTS FOUNDATION (US) 1982-12-21 US claimed
US-4273774-A 1,3-DIMETHYL-5-AMINOADMANTANE TOGETHER WITH CAFFEINE OR THEOPHYLLINE MERZ & CO. (DE) 1981-06-16 US claimed
US-4262089-A REAGENTS FOR IMMUNOASSAY SYVA COMPANY (US) 1981-04-14 US claimed