1-Methylxanthine

1-Methylxanthine

SCHEMBL16859909

Cn1c(=O)[nH]c2nc[nH]c2c1=O.O=c1[nH]c(=O)c2[nH]cnc2[nH]1

nearest known ligand 0.79

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2B P29275 10/20 0.79
ADORA2A P29274 7/20 0.79
ACHE P22303 1/20 0.68
GDA Q9Y2T3 1/20 0.68
ADORA3 P0DMS8 8/20 0.54
PDE4A P27815 5/20 0.54
PDE4B Q07343 5/20 0.54
PDE4C Q08493 5/20 0.54
PDE4D Q08499 5/20 0.54
ATAD2 Q6PL18 1/20 0.43
ADORA1 P30542 2/20 0.42
BLM P54132 2/20 0.42
PIK3CD O00329 1/20 0.42
ALPL P05186 1/20 0.42
TMIGD3 P0DMS9 1/20 0.42
CYP2C19 P33261 1/20 0.42
HIF1A Q16665 1/20 0.42
ALDH1A1 P00352 1/20 0.42
LMNA P02545 1/20 0.42
CYP3A4 P08684 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
1-Methylxanthine SCHEMBL10996 0.89 ADORA2B (1.00) ADORA2BADORA2AACHEGDAADORA3
1-Methylxanthine SCHEMBL28309011 0.88 ADORA2B (0.96) ADORA2BADORA2AACHEGDAADORA3
1-Methylxanthine SCHEMBL27529726 0.88 ADORA2B (0.96) ADORA2BADORA2AACHEGDAADORA3
1-Methylxanthine SCHEMBL9682658 0.88 ADORA2B (0.96) ADORA2BADORA2AACHEGDAADORA3
3-Methylxanthine SCHEMBL1892894 0.84 ADORA2B (0.77) ADORA2BADORA2AACHEGDAADORA3
Xanthine SCHEMBL31152020 0.84 GDA (0.96) ADORA2BADORA2AACHEGDAADORA3
Xanthine SCHEMBL692609 0.83 ADORA2B (0.54) ADORA2BADORA2AACHEGDAADORA3
Xanthine SCHEMBL29669592 0.82 GDA (1.00) ADORA2BADORA2AACHEGDAADORA3
Xanthine SCHEMBL2352524 0.82 GDA (1.00) ADORA2BADORA2AACHEGDAADORA3
Xanthine SCHEMBL4965 0.82 GDA (1.00) ADORA2BADORA2AACHEGDAADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9637731-B2 Heavy metal stabilization and methane inhibition during induced or naturally occurring reducing conditions in contaminated media INNOVATIVE ENVIRONMENTAL TECHNOLOGIES, INC. (US) 2017-05-02 US disclosed
US-20150183670-A1 HEAVY METAL STABILIZATION AND METHANE INHIBITION DURING INDUCED OR NATURALLY OCCURRING REDUCING CONDITIONS IN CONTAMINATED MEDIA INNOVATIVE ENVIRONMENTAL TECHNOLOGIES, INC. 2015-07-02 US disclosed