Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10985607 | 0.85 | ALDH1A1 (0.58) | SLC6A9PPARGKDM4EPPARAALDH1A1 | |
| SCHEMBL10989251 | 0.84 | SLC6A4 (0.56) | SLC6A9SLC6A4HRH3KDM4ESLC6A2 | |
| SCHEMBL10985198 | 0.83 | TAAR1 (0.41) | SLC6A4PPARGPPARASLC6A2SLC6A3 | |
| SCHEMBL10989204 | 0.82 | SLC6A4 (0.46) | SLC6A4HRH3PPARGKDM4EPPARA | |
| SCHEMBL10995397 | 0.82 | SLC6A4 (0.41) | SLC6A4HRH3KDM4ESLC6A2SLC6A3 | |
| SCHEMBL10992363 | 0.82 | SLC6A4 (0.45) | SLC6A4HRH3SLC6A2UTS2R | |
| SCHEMBL10991955 | 0.81 | KDM4E (0.48) | SLC6A4HRH3KDM4ESLC6A2SLC6A3 | |
| SCHEMBL10994963 | 0.81 | SLC6A4 (0.35) | SLC6A4HRH3KDM4EALDH1A1SLC6A2 | |
| SCHEMBL10994762 | 0.81 | CHRNB2 (0.51) | KDM4EFFAR1 | |
| SCHEMBL1919322 | 0.80 | SLC6A2 (0.47) | SLC6A4HRH3PPARGKDM4EPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4500541-A | Pharmacologically active cyclopropane derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1985-02-19 | — | — | US | disclosed |
| EP-0039771-B1 | CYCLOPROPANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PRODUCTION | MERCK PATENT GmbH (DE) | 1983-10-19 | — | — | EP | disclosed |
| EP-0039771-A1 | Cyclopropane derivatives, pharmaceutical compositions containing them and processes for their production | MERCK PATENT GmbH (DE) | 1981-11-18 | — | — | EP | disclosed |