Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.49 |
| ▸ | CCR2 | P41597 | 4/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846527 | 1.00 | ACHE (0.53) | ACHEROCK2CCR2ROCK1HTR7 | |
| SCHEMBL21672311 | 0.84 | HRH3 (0.56) | ACHEROCK2CCR2ROCK1CHRM2 | |
| SCHEMBL10997185 | 0.82 | ROCK2 (0.47) | ACHEROCK2CCR2ROCK1CHRM2 | |
| SCHEMBL3722397 | 0.82 | ALDH1A1 (0.55) | ROCK2CCR2ROCK1CHRM2CHRM3 | |
| SCHEMBL10367872 | 0.82 | ACHE (0.53) | ACHEHTR7CHRM2CHRM3HRH3 | |
| SCHEMBL25456999 | 0.82 | ACHE (0.53) | ACHEHTR7CHRM2CHRM3HRH3 | |
| SCHEMBL20233299 | 0.82 | KDM4E (0.59) | ACHEROCK2CCR2ROCK1HRH3 | |
| SCHEMBL1286699 | 0.80 | ACHE (0.79) | ACHEHRH3DRD2DRD4BCHE | |
| SCHEMBL358435 | 0.80 | ACHE (0.79) | ACHEHRH3DRD2DRD4BCHE | |
| SCHEMBL359069 | 0.80 | ACHE (0.79) | ACHEHRH3DRD2DRD4BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0132845-A2 | Novel 1,8-Naphthyridine derivatives, and process for preparation thereof | Dainippon Pharmaceutical Co., Ltd. (JP) | 1985-02-13 | — | — | EP | disclosed |