Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MMP1 | P03956 | 2/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10998978 | 1.00 | HDAC8 (0.41) | HDAC8HDAC6SMN1; SMN2MMP1MMP2 | |
| SCHEMBL6938966 | 0.92 | HDAC8 (0.44) | HDAC8HDAC6SMN1; SMN2MMP1MMP2 | |
| SCHEMBL10997112 | 0.85 | ALDH1A1 (0.49) | HDAC8HDAC6SMN1; SMN2MMP1MMP2 | |
| SCHEMBL10997106 | 0.85 | ALDH1A1 (0.49) | HDAC8HDAC6SMN1; SMN2MMP1MMP2 | |
| SCHEMBL10990796 | 0.84 | LMNA (0.50) | HDAC8HDAC6SMN1; SMN2MMP1MMP2 | |
| SCHEMBL10990800 | 0.84 | LMNA (0.50) | HDAC8HDAC6SMN1; SMN2MMP1MMP2 | |
| SCHEMBL17151526 | 0.84 | MMP1 (0.46) | HDAC8HDAC6SMN1; SMN2MMP1MMP2 | |
| SCHEMBL10997872 | 0.84 | HDAC1 (0.60) | HDAC8HDAC6SMN1; SMN2TP53MAPT | |
| SCHEMBL10997871 | 0.84 | HDAC1 (0.60) | HDAC8HDAC6SMN1; SMN2TP53MAPT | |
| SCHEMBL10992670 | 0.83 | KMT2A (0.42) | SMN1; SMN2MMP1MMP2MMP9TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4544670-A | ANTIPROTOZOA AGENTS, GASTROINTESTINAL AND CARDIOVASCULAR DISORDERS | WILLIAM H. RORER, INC. (US) | 1985-10-01 | — | — | US | disclosed |