Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.38 |
| ▸ | LMNA | P02545 | 11/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 9/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.38 |
| ▸ | HTT | P42858 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10862915 | 0.96 | MAPT (0.36) | MAPTLMNAALOX12SMN1; SMN2HTT | |
| SCHEMBL11315608 | 0.93 | SMN1; SMN2 (0.37) | MAPTLMNAALOX12SMN1; SMN2HTT | |
| SCHEMBL11329050 | 0.93 | MAPT (0.37) | MAPTLMNAALOX12SMN1; SMN2HTT | |
| SCHEMBL11102412 | 0.91 | SMN1; SMN2 (0.38) | MAPTLMNAALOX12SMN1; SMN2HTT | |
| SCHEMBL11085100 | 0.91 | LMNA (0.38) | MAPTLMNAALOX12SMN1; SMN2HTT | |
| SCHEMBL11321273 | 0.89 | LMNA (0.39) | MAPTLMNAALOX12SMN1; SMN2HTT | |
| SCHEMBL11319088 | 0.88 | IDO1 (0.33) | MAPTLMNAALOX12SMN1; SMN2HTT | |
| SCHEMBL11001538 | 0.84 | ALDH1A1 (0.35) | MAPTLMNAALOX12SMN1; SMN2HTT | |
| SCHEMBL11323918 | 0.84 | ALDH1A1 (0.51) | MAPTLMNAALOX12SMN1; SMN2ALDH1A1 | |
| SCHEMBL11323741 | 0.83 | LMNA (0.36) | MAPTLMNAALOX12SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4499101-A | HISTAMINE H2-ANTAGONISTS; ANTISECRETORY ANTIINFLAMMOATORY AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-02-12 | — | — | US | disclosed |
| US-4388319-A | ANTIHISTAMINES, ANTISECRETORY, ANTIINFLAMMATORY, HYPOTENSIVE AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-06-14 | — | — | US | disclosed |
| US-4282234-A | HISTAMINE BLOCKING AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-08-04 | — | — | US | disclosed |
| US-4271169-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-06-02 | — | — | US | disclosed |
| US-4215125-A | H-2 HISTAMINE RECEPTOR INHIBITORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-07-29 | — | — | US | disclosed |
| US-4191769-A | HISTAMINE ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-03-04 | — | — | US | disclosed |
| US-4170652-A | USED TO BLOCK HISTAMINE H2 RECEPTORS ANTISECRETORY, ANTIINFLAMMATORY | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-10-09 | — | — | US | disclosed |
| US-4152443-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-05-01 | — | — | US | disclosed |
| US-4118496-A | HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-10-03 | — | — | US | disclosed |
| US-4112104-A | UREA, THIOUREA OR GUANIDINE DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-09-05 | — | — | US | disclosed |
| US-4109003-A | N-(IMIDAZOLYL-METHYLTHIO-ALKYL) DERIVATIVES OF S-ALKYL ISOTHIOUREAS; ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-08-22 | — | — | US | disclosed |
| US-4107319-A | GUANIDINES, BLOCKING AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-08-15 | — | — | US | disclosed |
| US-4025527-A | H-2 HISTAMINE RECEPTOR INHIBITORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-05-24 | — | — | US | disclosed |