SCHEMBL11102412

SCHEMBL11102412

CNC(=S)NCCSCc1ccon1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 5/20 0.38
MAPT P10636 12/20 0.36
LMNA P02545 11/20 0.36
ALOX12 P18054 9/20 0.36
ALDH1A1 P00352 4/20 0.36
HPGD P15428 2/20 0.36
HTT P42858 6/20 0.35
MEN1 O00255 5/20 0.35
KMT2A Q03164 5/20 0.35
CYP1A2 P05177 2/20 0.35
CYP3A4 P08684 2/20 0.35
CYP2D6 P10635 2/20 0.35
CYP2C19 P33261 2/20 0.35
CYP2C9 P11712 1/20 0.35
RECQL P46063 1/20 0.35
KDM4E B2RXH2 1/20 0.35
PLA2G1B P04054 1/20 0.33
ATG4B Q9Y4P1 1/20 0.33
GAA P10253 1/20 0.33
TP53 P04637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11323741 0.92 LMNA (0.36) SMN1; SMN2MAPTLMNAALOX12ALDH1A1
SCHEMBL10999537 0.91 MAPT (0.38) SMN1; SMN2MAPTLMNAALOX12ALDH1A1
SCHEMBL11315608 0.88 SMN1; SMN2 (0.37) SMN1; SMN2MAPTLMNAALOX12ALDH1A1
SCHEMBL11329050 0.88 MAPT (0.37) SMN1; SMN2MAPTLMNAALOX12ALDH1A1
SCHEMBL10862915 0.87 MAPT (0.36) SMN1; SMN2MAPTLMNAALOX12ALDH1A1
SCHEMBL11085100 0.86 LMNA (0.38) SMN1; SMN2MAPTLMNAALOX12ALDH1A1
SCHEMBL11321273 0.84 LMNA (0.39) SMN1; SMN2MAPTLMNAALOX12ALDH1A1
SCHEMBL11312704 0.83 ACHE (0.42) SMN1; SMN2MAPTLMNAALDH1A1HPGD
SCHEMBL11531848 0.83 ALDH1A1 (0.33) SMN1; SMN2MAPTLMNAALDH1A1HPGD
SCHEMBL11319088 0.83 IDO1 (0.33) SMN1; SMN2MAPTLMNAALOX12ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4151288-A ANTHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1979-04-24 US claimed
US-4137234-A ANTIHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1979-01-30 US claimed
US-4438127-A AMIDOFORMIC AND AMIDOSULFONIC ACID HISTAMINE H2 ANTAGONISTS SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1984-03-20 US disclosed
US-4395419-A ANTIHISTAMINE, ANTISECRETORY AGENT SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1983-07-26 US disclosed
US-4308275-A ANTIGASTRIC ACID SECRETION, HISTAMINE RECEPTOR ANTAGONISTS SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1981-12-29 US disclosed
US-4307101-A ANTIHISTAMINES AND ANTISECRETORY AGENTS OF THE THIOUREA OR UREA DERIVATIVES 5,6,7,8-TETRAHYDROIMIDAZO(1,5A)PYRIDINE SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1981-12-22 US disclosed
US-4293699-A CONTAINING A BENZIMIDAZOLE OR 3-/5,6,7,8-TETRAHYDROIMIDAZO(1,5A)PYRIDINE, ANTIHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1981-10-06 US disclosed
US-4293697-A ANTIHISTAMINES SMITH, KLINE & FRENCH LABORATORIES LIMITED (GB) 1981-10-06 US disclosed
US-4287198-A ANTIHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1981-09-01 US disclosed
US-4230865-A ANTIHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1980-10-28 US disclosed
US-4228291-A INHIBITORS OF HISTAMINE ACTIVITY SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1980-10-14 US disclosed
US-4137234-A ANTIHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1979-01-30 US disclosed
US-4137237-A ANTIHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1979-01-30 US disclosed
US-4118502-A ANTIHISTAMINE SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1978-10-03 US disclosed
US-4070475-A THIOALKYL-, AMINOALKYL-, AND OXYALKYL- SUBSTITUTED GUANIDINES SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1978-01-24 US disclosed
US-4024271-A INHIBITORS OF HISTAMINE ACTIVITY SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1977-05-17 US disclosed
US-4022797-A PHARMACEUTICALS SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1977-05-10 US disclosed
US-4018931-A INHIBITION OF H-2 HISTAMINE RECEPTORS SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1977-04-19 US disclosed
US-3950353-A HISTAMINE INHIBITORS SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1976-04-13 US disclosed
US-3950333-A HISTAMINE INHIBITORS, OXYALKYL, THIOALKYL, AMINOALKYL DERIVATIVES SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1976-04-13 US disclosed