Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.51 |
| ▸ | CCR5 | P51681 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 2/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSC | P53634 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7419921 | 0.81 | SLC18A3 (0.60) | SLC18A3CCR5SIGMAR1 | |
| SCHEMBL9133642 | 0.81 | SLC18A3 (0.60) | SLC18A3CCR5SIGMAR1 | |
| SCHEMBL2440428 | 0.81 | SLC18A3 (0.60) | SLC18A3CCR5SIGMAR1 | |
| SCHEMBL7103234 | 0.79 | SLC18A3 (0.62) | SLC18A3CCR5SIGMAR1 | |
| SCHEMBL19184907 | 0.79 | CTSS (0.60) | CTSSCTSKCTSLCTSBCTSC | |
| SCHEMBL10999601 | 0.77 | MEN1 (0.47) | SLC18A3SIGMAR1HRH3 | |
| SCHEMBL6049169 | 0.76 | SIGMAR1 (0.61) | SLC18A3CCR5SIGMAR1 | |
| SCHEMBL28952283 | 0.75 | CYP2D6 (0.57) | CTSSCTSKSIGMAR1 | |
| SCHEMBL7392307 | 0.75 | SIGMAR1 (0.64) | SLC18A3CCR5SIGMAR1 | |
| SCHEMBL5087578 | 0.75 | SIGMAR1 (0.64) | SLC18A3CCR5SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0046289-B1 | SUBSTITUTED ENANTHOLACTAM DERIVATIVES AS ANTIHYPERTENSIVES, A PROCESS FOR PREPARING AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM, AND INTERMEDIATES | MERCK & CO. INC. (US) | 1985-11-27 | — | — | EP | claimed |