Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27304337 | 0.79 | HSD11B1 (0.45) | SLC18A3 | |
| SCHEMBL12128577 | 0.79 | MEN1 (0.53) | MEN1NPC1RAB9AKMT2ASLC18A3 | |
| SCHEMBL6851261 | 0.77 | SLC18A3 (0.48) | MEN1NPC1RAB9AKMT2ASLC18A3 | |
| SCHEMBL10999599 | 0.77 | SLC18A3 (0.51) | SLC18A3SIGMAR1HRH3 | |
| SCHEMBL12128324 | 0.75 | MEN1 (0.52) | MEN1NPC1RAB9AKMT2ASIGMAR1 | |
| SCHEMBL4339380 | 0.75 | SIGMAR1 (0.54) | SIGMAR1 | |
| SCHEMBL30082667 | 0.73 | MEN1 (0.57) | MEN1NPC1RAB9AKMT2AHRH3 | |
| SCHEMBL7419921 | 0.73 | SLC18A3 (0.60) | SLC18A3SIGMAR1 | |
| SCHEMBL2440428 | 0.73 | SLC18A3 (0.60) | SLC18A3SIGMAR1 | |
| SCHEMBL9133642 | 0.73 | SLC18A3 (0.60) | SLC18A3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0046289-B1 | SUBSTITUTED ENANTHOLACTAM DERIVATIVES AS ANTIHYPERTENSIVES, A PROCESS FOR PREPARING AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM, AND INTERMEDIATES | MERCK & CO. INC. (US) | 1985-11-27 | — | — | EP | claimed |