Sugi Predict

Sugi Predict / Compounds / SCHEMBL11001293

SCHEMBL11001293

SCHEMBL11001293

Cc1cc2c(cc1C)C(=O)CCO2

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ MAOB P27338 15/20 0.53
▸ MAOA P21397 1/20 0.53
▸ GRM5 P41594 8/20 0.45
▸ IMPDH2 P12268 1/20 0.45
▸ IMPDH1 P20839 1/20 0.45
▸ RAB9A P51151 2/20 0.41
▸ NPC1 O15118 1/20 0.41
▸ ALDH1A1 P00352 1/20 0.41
▸ HPGD P15428 1/20 0.41
▸ NFKB1 P19838 1/20 0.41
▸ NFKB2 Q00653 1/20 0.41
▸ RELA Q04206 1/20 0.41
▸ SMN1; SMN2 Q16637 1/20 0.41
▸ NPSR1 Q6W5P4 1/20 0.41
▸ KMT2A Q03164 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30558386 1.00 MAOB (0.53) MAOBMAOAGRM5IMPDH2IMPDH1
SCHEMBL10334865 0.89 IMPDH2 (0.42) MAOBMAOAGRM5IMPDH2IMPDH1
SCHEMBL31015967 0.85 MAOB (0.47) MAOBMAOAGRM5IMPDH2IMPDH1
SCHEMBL16841427 0.85 MAOB (0.47) MAOBMAOAGRM5IMPDH2IMPDH1
SCHEMBL12316639 0.85 MAOB (0.47) MAOBMAOAGRM5RAB9ANPC1
SCHEMBL25204542 0.85 MAOB (0.47) MAOBMAOAGRM5IMPDH2IMPDH1
SCHEMBL19433570 0.85 MAOB (0.47) MAOBMAOAGRM5RAB9ANPC1
SCHEMBL7940690 0.85 MAOB (0.56) MAOBMAOAGRM5IMPDH2IMPDH1
SCHEMBL1985927 0.85 MAOB (0.47) MAOBMAOAGRM5RAB9ANPC1
SCHEMBL86805 0.85 MAOB (0.62) MAOBMAOAGRM5RAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111909083-B Inhibitors of histone demethylase 赛尔基因昆蒂赛尔研究公司 2023-08-15 — — CN disclosed
EP-3160952-B1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RES INC (US) 2020-12-02 — — EP disclosed
EP-3741749-A1 HISTONE DEMETHYLASE INHIBITORS Celgene Quanticel Research, Inc. (US) 2020-11-25 — — EP disclosed
EP-3738960-A1 HISTONE DEMETHYLASE INHIBITORS Celgene Quanticel Research, Inc. (US) 2020-11-18 — — EP disclosed
CN-111909083-A Histone demethylase inhibitors 赛尔基因昆蒂赛尔研究公司 2020-11-10 — — CN disclosed
CN-106660982-B Histone demethylase inhibitors 赛尔基因昆蒂赛尔研究公司 2020-09-08 — — CN disclosed
US-10385047-B2 Histone demethylase inhibitors CELGENE QUANTICEL RESEARCH, INC. (US) 2019-08-20 — — US disclosed
US-10106534-B2 Histone demethylase inhibitors CELGENE QUANTICEL RESEARCH, INC. (US) 2018-10-23 — — US disclosed
US-20180251458-A1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RESEARCH, INC. (US) 2018-09-06 — — US disclosed
US-9994561-B2 Histone demethylase inhibitors CELGENE QUANTICEL RESEARCH, INC. (US) 2018-06-12 — — US disclosed
US-8263592-B2 Equilibrative nucleoside transporter ENT1 inhibitors JANSSEN PHARMACEUTICA NV (BE) 2012-09-11 — — US disclosed
US-8247431-B2 Heterocyclic hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-08-21 — — US disclosed
US-20100280025-A1 EQUILIBRATIVE NUCLEOSIDE TRANSPORTER ENT1 INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-11-04 — — US disclosed
US-20100280025-A1 EQUILIBRATIVE NUCLEOSIDE TRANSPORTER ENT1 INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-11-04 — — US disclosed
US-20100273768-A1 Inhibitors of Bruton's Tyrosine Kinase DEWDNEY NOLAN JAMES 2010-10-28 — — US disclosed
US-20100137362-A1 HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-03 — — US disclosed
US-4530919-A A 1,2,3,4-tetrahydronaphthalene carboxylic acid PFIZER INC. (US) 1985-07-23 — — US disclosed
US-4374148-A HYPOGLYCEMIC AGENTS PFIZER INC. (US) 1983-02-15 — — US disclosed
US-4305955-A ORAL HYPOGLYCEMIC AGENTS, CHROMAN-4-CARBOXYLIC ACID OR THIOCHROMAN-4-CARBOXYLIC ACID PFIZER INC. (US) 1981-12-15 — — US disclosed
US-4261988-A ANTICHOLESTEROL AGENTS USED IN ANIMAL HUSBANDRY BAYER AKTIENGESELLSCHAFT (DE) 1981-04-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180251458-A1 HISTONE DEMETHYLASE INHIBITORS KDM1B, KDM6A, KDM1A MAOB 517/4885MAOA 404/4885GRM5 1637/4885
US-10106534-B2 Histone demethylase inhibitors KDM1B, KDM6A, KDM1A MAOB 517/4885MAOA 404/4885GRM5 1637/4885
US-10385047-B2 Histone demethylase inhibitors KDM1B, KDM6A, KDM1A MAOB 517/4885MAOA 404/4885GRM5 1637/4885
US-20100273768-A1 Inhibitors of Bruton's Tyrosine Kinase BTK, SYK, LYN MAOB 1071/4885MAOA 1912/4885GRM5 3801/4885
US-20100137362-A1 HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, CAT, DNPH1 MAOB 393/4885MAOA 470/4885GRM5 1732/4885
US-20100280025-A1 EQUILIBRATIVE NUCLEOSIDE TRANSPORTER ENT1 INHIBITORS SLC29A1, SLC29A2, SLC43A3 MAOB 1632/4885MAOA 2192/4885GRM5 1775/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.