Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | HTR2B | P41595 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8370379 | 0.81 | ALDH1A1 (0.42) | TSHRKMT2AMTNR1AMTNR1BMEN1 | |
| SCHEMBL10810985 | 0.79 | ABAT (0.46) | TSHRAKR1C3AKR1C1NPSR1MAPT | |
| SCHEMBL31065849 | 0.79 | ABAT (0.46) | TSHRAKR1C3AKR1C1NPSR1MAPT | |
| SCHEMBL6660374 | 0.79 | EDNRA (0.42) | KMT2AAKR1C3AKR1C1HTR2CMAPT | |
| SCHEMBL11005069 | 0.79 | OPRM1 (0.40) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL10810614 | 0.78 | SIGMAR1 (0.45) | TSHRAKR1C3AKR1C1NPSR1SIGMAR1 | |
| SCHEMBL10611457 | 0.76 | FFAR1 (0.41) | TSHRKMT2AMTNR1AMTNR1BMEN1 | |
| SCHEMBL29443025 | 0.75 | AKR1C3 (0.50) | AKR1C3AKR1C1MAPTSMN1; SMN2GAA | |
| SCHEMBL289302 | 0.75 | AKR1C3 (0.50) | AKR1C3AKR1C1MAPTSMN1; SMN2GAA | |
| SCHEMBL11002363 | 0.74 | S1PR5 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4530919-A | A 1,2,3,4-tetrahydronaphthalene carboxylic acid | PFIZER INC. (US) | 1985-07-23 | — | — | US | disclosed |
| US-4374148-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1983-02-15 | — | — | US | disclosed |
| US-4305955-A | ORAL HYPOGLYCEMIC AGENTS, CHROMAN-4-CARBOXYLIC ACID OR THIOCHROMAN-4-CARBOXYLIC ACID | PFIZER INC. (US) | 1981-12-15 | — | — | US | disclosed |