Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.43 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.43 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11008812 | 0.91 | GPBAR1 (0.42) | NPSR1HPGDSMN1; SMN2KDM4EGAA | |
| SCHEMBL9690849 | 0.85 | KDM4E (0.39) | NPSR1HPGDSMN1; SMN2KDM4EGAA | |
| SCHEMBL11006883 | 0.79 | KDM4E (0.77) | HPGDKDM4EGAAALDH1A1CACNA1F | |
| SCHEMBL8080875 | 0.75 | ADORA2B (0.41) | NPSR1HPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL11004817 | 0.75 | KDM4E (0.47) | NPSR1HPGDKDM4EGAAALDH1A1 | |
| SCHEMBL9865258 | 0.75 | CYP3A4 (0.47) | NPSR1HPGDSMN1; SMN2KDM4EGAA | |
| SCHEMBL11007496 | 0.73 | KDM4E (0.67) | HPGDSMN1; SMN2KDM4EGAAALDH1A1 | |
| SCHEMBL11003915 | 0.72 | KDM4E (0.45) | NPSR1HPGDSMN1; SMN2KDM4EGAA | |
| SCHEMBL11267200 | 0.72 | NPSR1 (0.49) | NPSR1HPGDSMN1; SMN2KDM4EGAA | |
| SCHEMBL11003990 | 0.71 | KDM4E (0.64) | HPGDKDM4EGAAALDH1A1CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4532248-A | Administering 1,4-dihydropyridine derivative exhibiting positive inotropic activity | BAYER AKTIENGESELLSCHAFT (DE) | 1985-07-30 | — | — | US | disclosed |