Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | LATS1 | O95835 | 9/20 | 0.35 |
| ▸ | LATS2 | Q9NRM7 | 6/20 | 0.35 |
| ▸ | PRKCI | P41743 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | PRKCH | P24723 | 1/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.34 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11000644 | 0.81 | GSK3B (0.40) | LATS1LATS2PRKCI | |
| SCHEMBL11006980 | 0.80 | MAPK14 (0.41) | LATS1LATS2NPC1RAB9ALMNA | |
| SCHEMBL11005615 | 0.78 | ADORA2A (0.33) | LATS1LATS2PRKCIMAPTROCK2 | |
| SCHEMBL11003505 | 0.77 | GSK3B (0.43) | LATS1LATS2PRKCI | |
| SCHEMBL11005135 | 0.77 | PDE3B (0.36) | LATS1LATS2PRKCINPC1RAB9A | |
| SCHEMBL11004647 | 0.77 | ADORA2A (0.39) | LATS1LATS2PRKCINPC1LMNA | |
| SCHEMBL5021596 | 0.68 | NUDT1 (0.41) | — | |
| SCHEMBL11006461 | 0.66 | MAPT (0.46) | LATS1LATS2NPC1RAB9ALMNA | |
| SCHEMBL13233285 | 0.65 | KDM4E (0.49) | BRAFNPC1RAB9ALMNATP53 | |
| SCHEMBL16097154 | 0.65 | MAPT (0.43) | NPC1RAB9ALMNAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4503228-A | 2-(Pyridinyl)-4,5,6-pyrimidinetriamines | STERLING DRUG INC. (US) | 1985-03-05 | — | — | US | disclosed |
| US-4473571-A | 8-Substituted-2-(4-pyridinyl)-9H-purin-6-amines and their cardiotonic use | STERLING DRUG INC. (US) | 1984-09-25 | — | — | US | disclosed |