Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11006461 | 0.84 | MAPT (0.46) | MAPTLMNAKDM4ECYP2D6ADORA2A | |
| Hydrochloric Acid SCHEMBL11002866 | 0.82 | MAPT (0.43) | MAPTLMNACYP2D6CYP1A2ADORA2A | |
| SCHEMBL7210202 | 0.79 | MAPK14 (0.54) | MAPK14 | |
| SCHEMBL4063890 | 0.78 | DHPS (0.47) | KDM4ECYP1A2ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL980050 | 0.77 | MAPT (0.62) | MAPTLMNAKDM4ECYP2D6CYP1A2 | |
| SCHEMBL8490725 | 0.76 | ADORA2A (0.56) | MAPTLMNACYP2D6ADORA2AADORA1 | |
| SCHEMBL9791640 | 0.76 | ADORA2A (0.62) | MAPTLMNAKDM4ECYP2D6ADORA2A | |
| SCHEMBL30866250 | 0.75 | MAPT (0.59) | MAPTLMNAKDM4ECYP2D6CYP1A2 | |
| SCHEMBL28038683 | 0.74 | ADORA2A (0.52) | MAPTLMNACYP2D6ADORA2AADORA1 | |
| SCHEMBL11516053 | 0.74 | HRH4 (0.39) | MAPTLMNAKDM4ECYP1A2ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2976334-A1 | DIAMINOHETEROARYL SUBSTITUTED INDAZOLES | Bayer Pharma Aktiengesellschaft (DE) | 2016-01-27 | — | — | EP | claimed |
| WO-2014147144-A1 | DIAMINOHETEROARYL SUBSTITUTED INDAZOLES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-09-25 | — | — | WO | claimed |
| US-20170275267-A1 | SUBSTITUTED CYCLOALKENOPYRAZOLES AS BUB1 INHIBITORS FOR THE TREATMENT OF CANCER | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-09-28 | — | — | US | disclosed |
| US-9416125-B2 | — | — | 2016-08-16 | — | — | US | disclosed |
| EP-2976334-A1 | DIAMINOHETEROARYL SUBSTITUTED INDAZOLES | Bayer Pharma Aktiengesellschaft (DE) | 2016-01-27 | — | — | EP | disclosed |
| US-20150141372-A1 | SUBSTITUTED CYCLOALKENOPYRAZOLES AS BUB1 INHIBITORS FOR THE TREATMENT OF CANCER | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-05-21 | — | — | US | disclosed |
| WO-2014147144-A1 | DIAMINOHETEROARYL SUBSTITUTED INDAZOLES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150141372-A1 | SUBSTITUTED CYCLOALKENOPYRAZOLES AS BUB1 INHIBITORS FOR THE TREATMENT OF CANCER | BUB1, BUB1B, BUB3 | MAPT 1867/4885LMNA 2784/4885KDM4E 2231/4885 |
| US-20170275267-A1 | SUBSTITUTED CYCLOALKENOPYRAZOLES AS BUB1 INHIBITORS FOR THE TREATMENT OF CANCER | BUB1, BUB1B, BUB3 | MAPT 1867/4885LMNA 2784/4885KDM4E 2231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.