Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | ALPL | P05186 | 2/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11000258 | 0.89 | ALPL (0.52) | MAPTSMN1; SMN2LMNANPC1ALPL | |
| SCHEMBL1566612 | 0.86 | MAPT (0.57) | MAPTSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL11001807 | 0.85 | MAPT (0.54) | MAPTSMN1; SMN2LMNANPC1ALPL | |
| SCHEMBL6667136 | 0.85 | MAPT (0.51) | MAPTSMN1; SMN2NPC1ALPLRAB9A | |
| SCHEMBL15559606 | 0.84 | GAA (0.51) | MAPTSMN1; SMN2KDM4EPLA2G2AADORA3 | |
| SCHEMBL11004921 | 0.84 | MAPT (0.56) | MAPTSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL11000948 | 0.75 | SLC6A3 (0.48) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL11005353 | 0.75 | SAE1 (0.46) | MAPTLMNAOPRD1KDM4ECYP1A2 | |
| SCHEMBL31603878 | 0.74 | MEN1 (0.53) | MAPTSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL13118079 | 0.74 | SMN1; SMN2 (0.48) | MAPTSMN1; SMN2LMNANPC1ALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4544752-A | TREATMENT OF GOUT; ANTIARTHRITIC AGENTS | ELI LILLY AND COMPANY (US) | 1985-10-01 | — | — | US | disclosed |
| US-4346094-A | ENZYME INHIBITORS | ELI LILLY AND COMPANY (US) | 1982-08-24 | — | — | US | disclosed |
| EP-0048615-A1 | Improvements in or relating to 3-aryl-5-isothiazole derivatives | ELI LILLY AND COMPANY (US) | 1982-03-31 | — | — | EP | disclosed |