Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.46 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11000260 | 0.90 | KDM5A (0.45) | SAE1UBA2ALDH1A1LMNAMAPT | |
| SCHEMBL11004923 | 0.85 | PRKACA (0.45) | ALDH1A1MAPTHTTMEN1KMT2A | |
| SCHEMBL11001932 | 0.76 | KDM4C (0.48) | ALDH1A1HTTMEN1KMT2ACYP1A2 | |
| SCHEMBL11005342 | 0.75 | MAPT (0.54) | OPRD1ALDH1A1LMNAMAPTCA1 | |
| SCHEMBL19844014 | 0.71 | KDM4E (0.56) | SAE1UBA2ALDH1A1MAPTCA1 | |
| SCHEMBL8993003 | 0.71 | CA1 (0.78) | SAE1UBA2ALDH1A1LMNAMAPT | |
| SCHEMBL95380 | 0.70 | HPGD (0.56) | SAE1UBA2ALDH1A1LMNAMAPT | |
| SCHEMBL15831652 | 0.70 | ALDH1A1 (0.56) | SAE1UBA2ALDH1A1LMNAMAPT | |
| SCHEMBL13539015 | 0.70 | KDM4E (0.56) | SAE1UBA2ALDH1A1LMNAMAPT | |
| SCHEMBL27643975 | 0.69 | MAPT (0.49) | SAE1UBA2ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4544752-A | TREATMENT OF GOUT; ANTIARTHRITIC AGENTS | ELI LILLY AND COMPANY (US) | 1985-10-01 | — | — | US | disclosed |
| US-4346094-A | ENZYME INHIBITORS | ELI LILLY AND COMPANY (US) | 1982-08-24 | — | — | US | disclosed |
| EP-0048615-A1 | Improvements in or relating to 3-aryl-5-isothiazole derivatives | ELI LILLY AND COMPANY (US) | 1982-03-31 | — | — | EP | disclosed |