Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 6/20 | 0.47 |
| ▸ | CDK2 | P24941 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11005921 | 0.91 | MAPT (0.46) | CCNA2CDK2MEN1KMT2AMAPT | |
| SCHEMBL11008126 | 0.88 | CCNA2 (0.48) | CCNA2CDK2MEN1KMT2AMAPT | |
| SCHEMBL11004609 | 0.88 | VCAM1 (0.51) | CCNA2CDK2MEN1KMT2AMAPT | |
| SCHEMBL11034427 | 0.86 | CCNA2 (0.54) | CCNA2CDK2MEN1KMT2AMAPT | |
| SCHEMBL10954333 | 0.79 | CLK2 (0.52) | CCNA2CDK2MEN1KMT2AMAPT | |
| SCHEMBL10956535 | 0.78 | CLK2 (0.48) | CCNA2CDK2MEN1KMT2AMAPT | |
| SCHEMBL11003299 | 0.78 | VCAM1 (0.52) | MEN1KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL10956678 | 0.78 | CCNA2 (0.44) | CCNA2CDK2MEN1KMT2AMAPT | |
| SCHEMBL10957323 | 0.77 | CDK2 (0.63) | CCNA2CDK2MEN1KMT2AMAPT | |
| SCHEMBL10960186 | 0.76 | ALDH1A1 (0.56) | CCNA2CDK2MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0008047-B1 | 5(6)-(2-AMINO-5-THIAZOLOYL)BENZIMIDAZOLE-2-CARBAMIC ACID ESTERS AND THEIR SALTS, THEIR PREPARATION AND USE, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CIBA-GEIGY AG (CH) | 1985-12-04 | — | — | EP | disclosed |
| US-4386097-A | Benzimidazoles, processes for their preparation and pharmaceutical preparations containing such compounds | CIBA-GEIGY CORPORATION (US) | 1983-05-31 | — | — | US | disclosed |
| US-4297365-A | Benzimidazoles and pharmaceutical preparations containing such compounds | CIBA-GEIGY CORPORATION (US) | 1981-10-27 | — | — | US | disclosed |